| STUDY ON THE EFFECT OF T-2 TOXIN AND SELENIUM ON CD44 EXPRESSION IN THE CULTURED HUMAN FETAL CHONDROCYTES IN VITRO |
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| 作者姓名： | 谢龙 曹峻岭 岳燕 朱建宏 张增铁 张富军 李思远 |
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| 作者单位： | Institute of Endemic Diseases，Institute of Endemic Diseases，Institute of Endemic Diseases，Second Hospital of Xi’an Jiaotong University，Institute of Endemic Diseases，Institute of Endemic Diseases，Institute of Endemic Diseases Medical School of Xi'an Jiaotong University，Xi'an 710061，China，Medical School of Xi'an Jiaotong University，Xi'an 710061，China，Medical School of Xi'an Jiaotong University，Xi'an 710061，China，Xi’an710004，China，Medical School of Xi'an Jiaotong University，Xi'an 710061，China，Medical School of Xi'an Jiaotong University，Xi'an 710061，China，Medical School of Xi'an Jiaotong University，Xi'an 710061，China |
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| 基金项目： | ThisstudywassupportedbytheNationalNaturalScienceFoundationofChina(No .3 0 170 83 1) |
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| 摘 要： | KBD (Kashin BeckDisease)isasevere ,en demicosteoarthrosisandthepathogenesisofitisstillapendentproblem1] .WiththestudyofetiologyofKBD ,thehypothesisofselenium deficiencyinthesurroundingandfoodcontaminatedbyfungaltoxinisanoticeableone .The pathologicalfeaturesofKBDarethedegenerationandnecrosisofthearticu larcartilage ,disorderofmetabolismofcartilagematrix .Thestudyontheosteoarthrosissuggeststhatthereductionoftheaggregationandincreaseofdeg radationofaggrecanareinitialaffairsifcartilagehasdeg…
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STUDY ON THE EFFECT OF T-2 TOXIN AND SELENIUM ON CD44 EXPRESSION IN THE CULTURED HUMAN FETAL CHONDROCYTES IN VITRO |
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| Xie Long,Cao Junling,Yueyan,Zhu Jianhong ,Zhang Zengtie,Zhang Fujun,Li Siyuan Institute of Endemic Diseases,Medical School of Xi'an Jiaotong University,Xi'an ,China..STUDY ON THE EFFECT OF T-2 TOXIN AND SELENIUM ON CD44 EXPRESSION IN THE CULTURED HUMAN FETAL CHONDROCYTES IN VITRO[J].Academic Journal of Xi’an Jiaotong University,2003,15(1). |
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| Authors: | Xie Long Cao Junling Yueyan Zhu Jianhong Zhang Zengtie Zhang Fujun Li Siyuan Institute of Endemic Diseases Medical School of Xi'an Jiaotong University Xi'an China |
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| Institution: | 1. Institute of Endemic Diseases, Medical School of Xi'an Jiaotong University, Xi'an 710061, China
2. Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China |
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| Abstract: | Objective To investigate the effect on the structure of reestablished cartilage in vitro and CD44 expression on chondrocytes and compare the inducing effect on the reestablished cartilage in vitro between cortical bone matrix gelatin and cancellous bone matrix gelatin. Methods To plant human fetal chondrocytes on the BMG, the damage of the cultured chondrocytes was observed by the optical microscope (HE staining). The immunohistochemistry of CD44 was quantitative analysis by the image collection and analysis system. Results With the increasing concentration of T 2 toxin, the damage of chondroytes was more and more evident and CD44 expression was lowered. After adding selenium, the damage was relieved and CD44 expression increased. The density of chondrocytes on the cortical bone matrix gelatin was much higher than that on the cancellous bone matrix gelatin. Conclusion T 2 toxin can lower the CD44 expression on the chondrocytes and adding selenium can relieve the damage caused by T 2toxin and increased CD44 expression. The inducing effect on reestablished cartilage in vitro of cortical bone matrix gelatin was much higher than that of cancellous bone matrix gelatin. |
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| Keywords: | T 2toxin selenium (Se) bone matrix gelatin (BMG) chondrocytes CD44 |
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