| 头孢羟氨苄分散片相对生物利用度研究 |
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| 引用本文： | 姬海红,唐新娟,景岗,柳晓泉.头孢羟氨苄分散片相对生物利用度研究[J].西安交通大学学报(医学版),2000,21(5):420-421. |
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| 作者姓名： | 姬海红 唐新娟 景岗 柳晓泉 |
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| 作者单位： | 陕西东盛药业股份有限公司，西安 710075 |
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| 摘 要： | 目的 研究头孢羟氨苄分散片与颗粒剂的相对生物利用度。方法 采用高效液相色谱法(HPLC)测定18名男性健康志愿者单剂量交叉口服500mg头孢羟氨苄分散片与颗粒剂后的血药浓度，计算两者的相对生物利用度。结果 头孢羟氨苄分散片与颗粒剂的Tmax分别为(1..61±0..44)h和(1..58±0..35)h；Cmax分别为(16..0±2..06)mg/L和(16..4±1..99)mg/L;t１／２分别为(2..22±0..26)h和(2..22±0..26)h；药时曲线下面积AUC分别为(60..2±9..79)mg·h/L和(60..7±9..76)mg·h/L；头孢羟氨苄分散片相对生物利用度为(99..3±6..51)%。结论 两种制剂具有生物等效性。
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| 关 键 词： | 头孢羟氨苄分散片 生物利用度 HPLC |
| 文章编号： | 0258-0659(2000)05-0420-02 |
| 修稿时间： | 2000年3月7日 |
The bioavailability of cefadroxildispersible tablet |
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| Abstract: | Objective To study the relative bioavailability of cefadroxil dispersible tablet and granule. Methods The study was conducted in 18 male healthy volunteers. After single oral dose of 500mg cefadroxil dispersible tablet or granule was given, the blood drug concentrations were deter mined by HPLC and the bioavailability were calculated. Results of two dosages were(1.61±0.44)h and (1.58±0.35)h respectively; were(16.0±2.06)mg/L and (6.4±1.99)rmg/L respectively;were (2. 22±0. 26) h and (2. 22±0. 26) h respectively; AUC were (60.2±9.79)mg·l/L and (60.7±9.76)mg·h/L respectively. The bioavailability of cefadroxil dispersible tablet was(99.3±6.51)％. Conclusion The two dosage forms are bioequivalent. |
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| Keywords: | cefadroxil dispersible tablets bioavailability HPLC |
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