| 硫氮酮对肾移植患者环孢素药动学和超氧化物歧化酶水平的影响 |
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| 引用本文： | 闫正华,王茂义,董卫华. 硫氮酮对肾移植患者环孢素药动学和超氧化物歧化酶水平的影响[J]. 西安交通大学学报(医学版), 1997, 0(2) |
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| 作者姓名： | 闫正华 王茂义 董卫华 |
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| 作者单位： | 西安第一附属医院药剂科!西安，710061，西安第一附属医院药剂科!西安，710061，西安第一附属医院药剂科!西安，710061 |
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| 摘 要： | 分别对4例及6例肾移植患者单用环孢素（CyclosporineCsA）与合用硫氮酮后CSA的药物动力学变化进行研究，并观察了其中9例患者血药浓度达峰时血浆超氧化物歧化酶（SOD）活性的变化。结果表明：肾移植患者CsA药动学参数个体差异大，合用硫氮酮后，CsA的β和T1／2α显著性降低，T1/2β显著性升高，峰浓度有一定升高，其它参数无明显改变（P>0．05）。合用硫氮酮后血浆SOD活性有一定增大。
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| 关 键 词： | 环孢素 硫氮■酮 药物动力学 SOD |
THE EFFECT OF DILTIAZEM ON PHARMACOKINETICS OF CYCLOSPORINE AND SUPEROXIDE DISMUTASE LEVELS IN KIDNEY TRANSPLANT PATIENTS |
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| Yan Zhenghua, Wang Maoyi, Dong Weihua. THE EFFECT OF DILTIAZEM ON PHARMACOKINETICS OF CYCLOSPORINE AND SUPEROXIDE DISMUTASE LEVELS IN KIDNEY TRANSPLANT PATIENTS[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1997, 0(2) |
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| Authors: | Yan Zhenghua Wang Maoyi Dong Weihua |
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| Abstract: | The changes of CsA,s pharma-cokinetics were studied in four kidney transplant pa-tients administered CsA and six patients adminis-tered CsA and Diltiazem. We observed the changes of SOD activity in nine patients when blood concen-tration of CsA getting peak. CsA concentrations were determined by FPIA. Pharmacokinetic param-eters were calculated by 3P87 program. The results indicated that CsA,s pharmacokinetics parameters of kidney transplant patients were greatly different when Diltiazem used. 9 and T1/.2a. of CsA descended evidently. T1/2β ascended remarkably. Peak concen-tration was ascendent. Other parameters had no changes. When using Diltiazem, SOD activity in serum had some changes. |
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| Keywords: | Cyclosporine(CsA) Diltiazem pharmacokinetics SOD |
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