不孕妇女子宫内膜微量元素与黄体功能的关系

对不明原因不孕19例以及已育健康妇女14名为对照组，测定黄体中期子宫内膜中锌、铜、铁、锰含量，以探讨子宫内膜微量元素含量与黄体功能的关系。结果表明：不孕组子宫内膜锌含量显著降低（P〈0．001），铜、锰水平明显高于对照组（P＜0．05）。锌／铜、铁／铜比率显著低于对照组（P＜0．001，P＜0．05）；黄体中期不孕组血清孕酮和泌乳素浓度亦显著低于对照组分别为（33．72士9．35）nmol／L，vs．（50．91士12．of）nmol／L，P<0．001，和（21．37土7．43）μg／L，vs．（30．46士9．22）μg／L，P<0.05]，且对照组内膜锌与血清孕酮水平呈正相关（r=0．57996，P<0．05）。提示：黄体中期内膜锌含量、锌／铜及铁／铜比值与子宫内膜的分泌期改变密切相关，测定内膜锌／铜、铁／铜比率可用于评价黄体功能及不明原因不孕妇女的预后。

THE RELATIONSHIP BETWEEN ENDOMETRIAL TRACE ELEMENT AND CORPUS LUTEUM FUNCTION IN UNEXPLAINED INFERTILE WOMEN

To investigate the effectof endometrial trace elements on corpus luteumfunction in unexplained infertile women. Methods:Measurement of the endometrium zinc(Zn), Copper(Cu), iron (Fe) and manganese (Mn) in the midluteal phase of the menstrual cycles; RIA of FSH,LH, PRL, estradiol and progesterone (P) ; and endometrial biopsy were performed. Results: In infertile group, compared to the control group, therewere lower mean Zn (P <0. 001 ), higher mean Cuand Mn levels (P < 0. 05 ), a lower ratio of meanZn/Cu and Fe/Cu (P < 0. 001, P <0. 05, respectively) in the mid-luteal chase endometriuml; Theserum P and PRL were significantly lower in infertile group than those in control group (33. 72 ± 9. 35nmol/L vs. 50. 91± 12. 01 nmol/L, and 21. 37± 7.43 μg/L vs. 30. 46± 9. 22 μg/L, P<0. 001, P <0.05, respectively), a positive correlation existed between the endometrium Zn and serum P in the control group (γ = 0. 57996, P < 0. 05). Conclusion:Endometrium Zn, ratio of Zn/Cu and Fe/Cu may bein close relation with the endometrial secretory sta-ins in the mid-luteal phase, it can be used for clinical evaluation of corpus luteum function and prognosis of unexplained infertile women.