| INVESTIGATION OF REALGAR IN THE TREATMENT FOR MULTIPLE MYELOMA |
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| 引用本文： | 王梦昌,刘陕西,李信民. INVESTIGATION OF REALGAR IN THE TREATMENT FOR MULTIPLE MYELOMA[J]. 西安交通大学学报(英文版), 2005, 17(1): 94-96 |
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| 作者姓名： | 王梦昌 刘陕西 李信民 |
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| 作者单位： | Department of Hematology，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，Department of Hematology，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，Department of Hematology，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China |
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| 摘 要： | Multiplemyeloma(MM)isaB cellmalignan cycharacterizedbyplasmacellsinthebonemarrow thatproducemonoclonalimmunoglobulin.Forthe highexpressionofmultipledrugresistantgenein theMMcells,MMhaslowerrecoveryratebut higherrelapserate.Itwasreportedrecentlythat As2O3…
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| 关 键 词： | 鸡冠石 多发性骨髓瘤 白细胞间介素6 治疗方法 |
INVESTIGATION OF REALGAR IN THE TREATMENT FOR MULTIPLE MYELOMA |
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| Wang Mengchang,Liu Shaanxi,Li Xinmin. INVESTIGATION OF REALGAR IN THE TREATMENT FOR MULTIPLE MYELOMA[J]. Academic Journal of Xi’an Jiaotong University, 2005, 17(1): 94-96 |
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| Authors: | Wang Mengchang Liu Shaanxi Li Xinmin |
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| Affiliation: | Department of Hematology, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China |
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| Abstract: | Objective To observe the clinical effect of realgar on multiple myeloma and to investigate its mechanism. Methods MTT and double antibody cramped ELISA assay were used to detect the activity of interleukin-6(IL-6) and level of soluble interleukin-6 receptor(sIL-6R) of the bone marrow supernant in 15 multiple myeloma patients treated by realgar or not. Results The activity of interleukin-6 and level of soluble interleukin-6 receptor of multiple myeloma patients were significantly higher than that of control group(P<0.01). They were not apparently decreased after realgar was used for 50 days(P>0.05).The interleukin-6 activity of stage Ⅲ patients were much higher than that of stage Ⅰ or Ⅱ(P<0.05). There was no difference of the level of soluble interleukin-6 receptor between two groups(P>0.05). For the 15 patients who were treated by using realgar, 3 got complete remission(CR), 5 got partial remission(PR), 7 came to not remission(NR). Conclusion Realgar could not decrease the activity of interleukin-6 and level of soluble interleukin-6 receptor so as to inhibit the proliferation of tumor cells. |
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| Keywords: | realgar multiple myeloma interleukin-6 therapy |
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