乙型肝炎疫苗无弱应答者复种效果观察

目的　观察乙肝疫苗无弱应答者复种后近、远期效果。方法　严格筛选无弱应答者 ,用3针加倍剂量全程接种 ,随机分组观察皮内和肌肉接种效果。于接种首针后 1、2、8个月随访采血 ,检测乙肝三项指标 ,做近期观察。结果　皮内接种效果不如肌肉接种 ;接种 3针似不能取得比 1、2针更好的效果 ;8个月观察抗体应答率虽高达 90 % ,但第 8个月时已见抗体水平下降 ,与一般人群接种应答规律显著不同。结论　从近期效果看 ,复种是否能取得较好的远期效果 ,尚待观察研究。

Efficacy of hepatitis B revaccination in non-and-hyporesponders to the vaccine

Objective To evaluate short and long term efficacy of hepatitis B revaccination in the non and hyporesponders. Methods Screening with strict diagnosis criteria was carried out, and all the non and hyporesponders were given three 2 fold dose vaccines randomly by intradermal or intramuscular route. The blood samples were collected in 1,2 and 8 months following the first injection in order to evaluate short term efficacy.Results The intradermal route was not as effective as the intramuscular route. The revaccination with 3 doses was not more effective than that with 1 or 2 doses. Although the responsive rate to the vaccine during 8 months reached 90%,the antibody GMT dropped in the 8th month, which appeared significantly different from the antibody presentation in general populations.Conclusion From the short term observation, it is difficult to determine whether revaccination could produce a satisfactory long term effect.Further follow up surveys are necessary.