川牛膝提取物抗生育作用的实验研究

本实验观察了川牛膝3种提取物,即苯提取物,乙酸乙酯提取物和醇提取物对小鼠抗生育和抗着床作用。结果表明,苯提取物250 mg/kg对雌鼠有明显的抗生育作用,无1例怀孕,有效率达100%,乙酸乙酯提取物250mg/kg有效率达63.7%,而500 mg/kg有效率可达90%以上,醇提取物500 mg/kg抗生育效果为40～54%。抗着床实验表明,苯提取物500 mg/kg有效率达100%,乙酸乙酯提取物500mg/kg有效率为66.7%,醇提取物500 mg/kg有效率为40%.以上说明3种川牛膝提取物都有一定的抗生育和抗着床作用,但以苯提取物最为显著。

EXPERIMENTAL STUDY ON ANTIFERTILITY EFFECT OF CYATHULA OFFICINALIS KUAN

The antifertility and antinidation effects of three extracts (benzol, ethyl acetate and alcohol) of Cyathula Oficinalis Kuan on mice were observed. The results indicate that the benzol extract had significant antifertility action. Its effective rate of antifertility was 100%, when 250 mg/kg was given orally. As compared with control, when 250 mg/kg ethyl acetate extract was given, the rate of antifertility was 63.7%. If 500 mg/kg ethyl acetate extract was given the effective rate of antifertility increased over 90%. However, when 250～500 mg/kg alcohol extract was given, the rate of antifertility was only 40～54%. The study of antinidation showed that the benzol extract (500 mg/kg )could effectively prevent implatation. The rate of antinidation was 100%, and yet the ethyl acetate and alcohol extracts were 66.7% and 40% repectively. The results suggest that the three extracts of Cyathula Officinalis Kuan all had antifertility effect, but the action of benzol extract was more effective than other two extracts.