二色补血草止血作用的药理研究

二色补血草水煎剂15g(生药)/kg,乙醇提取液15g(生药)/kg灌胃,均使大白鼠的出血时间明显缩短,对凝血时间无明显影响。二色补血草醇提取液20g(生药)/kg灌胃,对大白鼠实验性动脉血栓形成有明显促进作用。因为动脉血栓形成主要与血小板的粘附和聚集有关。结果提示二色补血草止血作用机理可能与其促进血小板粘附和聚集作用有关。

PHARMACOLOGICAL STUDIES OF HEMOSTATIC EFFECT OF LIMONIUM BICOLOR(BGE) O KTZE

The decoction of Limonium bicolor (Bge.) O. Ktze (LBK) (15g/kg, corresponding to crude drugs) and the alcoholic extractive fluid of LBK (15g/kg. corresponding to crude drugs) were given orally to two groups of rats two times dailyrespectively. After four days, bleeding time of rats was shortened significantly with no distinet effect on coagulation time. The alcoholic extractive fluid (20g/kg, corresponding to crude drugs) was given orally to rats two times dally. After four days, experimental arterial thrombosis was promoted significantly. Obviously, arterial thrombosis is mainly related to platelet adhesion and aggregation, suggesting that the mechanism of the hemostatic effect of LBK may be related to its promotion of platelet adhesion and aggregation. When the decoction of LBK was given orally to mice, LD_(50) was 58.37 ± 10.77g/kg(p = 0.95).