| PREVENTIVE EFFECT OF BORON ON DAMAGE TO CARTILAGE OF RATS WITH INTAKE EXCESSIVE FLUORIDE |
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| 作者姓名： | 许鹏 郭雄 曹晖 康龙丽 杜晓阳 张增铁 耿冬 |
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| 作者单位： | Institute of Endemic Diseases，Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University)，Ministry of Education，Xi'an 710061，China，Institute of Endemic Diseases，Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University)，Ministry of Education，Xi'an 710061，China，Institute of Endemic Diseases，Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University)，Ministry of Education，Xi'an 710061，China，Institute of Endemic Diseases，Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University)，Ministry of Education，Xi'an 710061，China，Institute of Endemic Diseases，Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University)，Ministry of Education，Xi'an 710061，China，Institute of Endemic Diseases，Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University)，Ministry of Education，Xi'an 710061，China，Institute of Endemic Diseases，Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University)，Ministry of Education，Xi'an 710061，China |
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| 基金项目： | ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina(No.39970663),theScienceFoundationof ShaanxiProvince(No.98SM48),theScientificFoundationofMinistryofPublicHealthofChina(No.98 1 24). |
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| 摘 要： | Althoughfluorideinthebodymayhelpthe growthofbonesandteethinitsrangeofsafety,ex cessiveintakeoffluoridefromtheenvironmentcan damagetissuesandorgansinhumanandanimal, thusinducingskeletalfluorosis(SF)1,2].Control lingoffluoridesources(suchastodefluoridate…
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| 关 键 词： | 氟化物 硼 软骨 鼠 身体损伤 |
PREVENTIVE EFFECT OF BORON ON DAMAGE TO CARTILAGE OF RATS WITH INTAKE EXCESSIVE FLUORIDE |
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| Xu Peng,GUO Xiong,Cao Hui,Kang Longli,Du Xiaoyang,Zhang Zengtie,Geng Dong.PREVENTIVE EFFECT OF BORON ON DAMAGE TO CARTILAGE OF RATS WITH INTAKE EXCESSIVE FLUORIDE[J].Academic Journal of Xi’an Jiaotong University,2005,17(1):36-39. |
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| Authors: | Xu Peng GUO Xiong Cao Hui Kang Longli Du Xiaoyang Zhang Zengtie Geng Dong |
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| Institution: | Institute of Endemic Diseases, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China |
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| Abstract: | Objective To investigate and analyze the preventive effect of boron on the cartilage damage in rats with intake excessive fluoride. Methods Fifty-ix Sprague-Dawley rats were divided into the control group (C, intake distilled water), the excessive fluoride dose group (EF, intake distilled water with 100 ppm F-) and the boron prevention group (P, intake distilled water with 100 ppm F- as well as the supplemental boron dietary). 3 to 5 months later, fluorine contents in serum, RNA contents in costal cartilage were assayed. The morphological changes in tibia growth plate cartilage (GPC) in rats were observed. Results Although exposed to the same dose of fluoride, the fluorine contents in serum in rats of P group decreased notably compared with those of EF group, the damage of tibia GPC under optical and electron microscope lessened significantly, and RNA contents in costal cartilage increased obviously in the 3rd month. Conclusion Boron added could decrease the fluorine level in the body and relieve the toxic symptom of excess fluoride, and thus boron has a preventive effect on skeletal fluorosis. |
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| Keywords: | fluoride boron prevention cartilage Rat |
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