| INHIBITORY EFFECTS OF THE ALKALOIDS FROM Radix Caulophylli ON THE PROLIFERATION OF HUMAN VASCULAR ENDOTHELIAL CELL |
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| 作者姓名： | 李义平 贺浪冲 |
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| 作者单位： | Department of Pharmocology，Medical School of Xi'an Jiaotong University，X'an 710061，China，Department of Pharmocology，Medical School of Xi'an Jiaotong University，X'an 710061，China |
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| 摘 要： | Angiogenesisplaysaveryimportantrolein tumorgrowthandmetastasis1,2].Tumorssignalthe needforabloodsupplybysecretinggrowthfactors thattriggerangiogenesis,includingbasicfibroblast growthfactor(bFGF),vascularendothelialgrowth factor(VEGF)andplatelet deriveden…
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| 关 键 词： | 生物碱 人体组织 血管 细胞膜 抑制剂 药材化学 |
| 文章编号： | 1671-8267（2005）02-0185-03 |
INHIBITORY EFFECTS OF THE ALKALOIDS FROM Radix Caulophylli ON THE PROLIFERATION OF HUMAN VASCULAR ENDOTHELIAL CELL |
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| Li YiPing;He LangChong.INHIBITORY EFFECTS OF THE ALKALOIDS FROM Radix Caulophylli ON THE PROLIFERATION OF HUMAN VASCULAR ENDOTHELIAL CELL[J].Academic Journal of Xi’an Jiaotong University,2005,17(2):185-187,192. |
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| Authors: | Li YiPing;He LangChong |
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| Abstract: | Objective To find an angiogenetic inhibitor from Radix Caulophylli (RC). Methods The extract of Radix Caulophylli was obtained by using 95% alcohol in water as solvent. Then, the total alkaloids of Radix Caulophylli was isolated from the extract by using a positive ion exchange resin column. An active part was found by a screening model of cell membrane chromatography (CMC) and further tested by the MTT method with emodin as a control. Results The total alkaloids of Radix Caulophylli was the active part by CMC and could significantly inhibit proliferation of ECV304 cells in MTT test. The inhibitory rate was 56.06% while the concentration of the total alkaloids of Radix Caulophylli was 19.63μg/mL. Conclusion The total alkaloids from Radix Caulophylli may be a new angiogenetic inhibitor, and mechanism of the total alkaloids on inhibitory angiogenesis still need to be further investigated. |
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| Keywords: | Radix Caulophylli cell membrane chromatography MTT angiogenetic inhibitor |
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