先天性心脏病心内膜—心肌活检的电镜初步观察

本文报导了应用心内膜—心肌活检法对四例先天性心脏病人的心肌组织电镜检查结果。在电镜下所见心肌的肌膜、闰盘、线粒体、肌微丝和细胞核等的变化,都表明心肌纤维基本上处于功能代偿期。但随着年龄的增长,出现了程度不等的退行性改变,所以及时作心肌活检,不但可以了解心肌发生超微病变的动态,更重要的是能够提示外科手术的理想时机。

A Preliminary Electron Microscopic Observation On Endocardial and Myocardial Biospy in Congenital Heart Disease

This article reports the results of observation on the endocardium andmyocardium obtained from 4 cases (the age of 10-35) of congenital heartdisease by endomyocardial catheter biospy. The materials of two cases wereobtained from the left ventricules and the rest from the right ones. Electromicroscopically, all these materials showed the following dif-ferent structural changes in the myocardial fibres: 1) a conspicuous bul-ging of the sarcolemma and an active pinocytosis; 2) a cistern-like disten-tion of the interspaces between the double membranes of the intercalateddiscs; 3 ) multiplication and hypotrophy of the mitochondra and vacuolardegeneration; 4 ) disintergration, dissolution and disappearance of themicrofilaments; and 5)an increase in the wrinkles of the neuclear mem-branes. The Changes mentioned above indicate that the myocardium in thesecases is in a functional compensatory period and in some aged patientsslightly degenerative changes are found in the myocadium.