| 自身免疫性甲状腺炎和甲亢原位免疫电镜研究 |
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| 引用本文： | 苏敏,牛恕淼.自身免疫性甲状腺炎和甲亢原位免疫电镜研究[J].西安交通大学学报(医学版),1991(3). |
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| 作者姓名： | 苏敏 牛恕淼 |
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| 作者单位： | 西安医科大学病理解剖学教研室
(苏敏)，西安医科大学病理解剖学教研室(牛恕淼) |
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| 摘 要： | 利用ABC免疫酶技术和一组淋巴细胞亚群、巨噬细胞,HLA-DR抗原的单克隆抗体及免疫电镜技术观察了10例甲状腺炎,7例甲亢伴甲状腺炎,6例甲亢。结果发现甲状腺内有大量活化T淋巴细胞浸润。引人注目地是甲状腺上皮细胞可异常表达DR抗原,且随着淋巴细胞浸润的增多,炎性破坏加重,甲状腺上皮细胞DR抗原的异常表达亦增多。I_2~+、T_8~+、T_4~+细胞、M_5~+细胞和Leu7~+细胞均可与甲状腺滤泡上皮细胞接触并侵入上皮细胞内。免疫活性细胞的直接杀伤作用,可能是甲状腺上皮细胞受损的重要因素。
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| 关 键 词： | 自身免疫病 甲状腺炎 甲状腺机能亢进 淋巴细胞 电子显微镜 |
IN SITU ANALYSIS OF LYMPHOCYTE SUBPOPULATIONS AND HLA-DR-POSITIVE EPITHELIAL CELLS BY IMMUNOELECTRON MICROSCOPY IN AT AND GD |
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| Su Min,Niu Shumiao.IN SITU ANALYSIS OF LYMPHOCYTE SUBPOPULATIONS AND HLA-DR-POSITIVE EPITHELIAL CELLS BY IMMUNOELECTRON MICROSCOPY IN AT AND GD[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1991(3). |
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| Authors: | Su Min Niu Shumiao |
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| Institution: | Su Min;Niu Shumiao Department of puthology |
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| Abstract: | Tru--cut specimens thyroid tissues from 10 casesof autoimmune thyroiditis (AT), 7 cases ofthyrotoxicosis with thyroiditis and 6 cases of Gravesdisease (GD) were analyzed by immunoelectronmieroscopy using monoclonal antibodies specific for Bcells, T cell subsets, macrophages natural killer cellsand HIA--DR antigen. We found that many activatedT cell were present in thyroid gland. Most important-ly, thyroid epithelial cells also expressed HLA--DRantigen and the number of DR~+ thyroid epithelial cellswas significantly inereased in thyroid gland with intenselymphocytes infiltration and severe destruction ofthyroid architecture I_2~+ cells, T_8~+ cells, M_5 cells,T_4~+, cells, and Leu 7~+ cells were frequenly found to bem close contact with the thyroid epithelial cells and toinvade them mediated by cytotoxic T cells maybe to blame for the contribution of the destructionof the thyroid gland. |
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| Keywords: | autoimmune disease thyroidites Hyperthyroidism lymphocyte electron microscopy |
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