| THE CLINICAL SIGNIFICANCE OF MONITORING CARBOHYDRATE ANTIGEN CA50 IN COLORECTAL CARCINOMA |
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| 引用本文： | 王康,刘浩,许延发. THE CLINICAL SIGNIFICANCE OF MONITORING CARBOHYDRATE ANTIGEN CA50 IN COLORECTAL CARCINOMA[J]. 西安交通大学学报(英文版), 1998, 0(2) |
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| 作者姓名： | 王康 刘浩 许延发 |
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| 作者单位： | Department of General Surgery，First Clinical Medical College，Xi'an Medical University，Xi'an 710061 |
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| 摘 要： | AntigenssuchasQ-fetoproteinandcarcinoembryonicantigenhavebeenusedasmarkersforthediagnosisandpostoperativeevaluationofpatientswithmalignanttumors.Lindholmetaldetectedamalignanttumorcelllinebyusinghybridomatechniquein1983,themonoclonalantibodiessecretedbythecelllineweredefinedasC50.TheantigenrecognizedbyC50monoclonalantibodywasnamedCA50.Itwasraisedagainstacolorectaladenocarcinomacellline.CA50antigenexistsonthecellsurfaceintheformoflipidorlipoproteincomplex,belongingtothemarkerofsphingoglycoli…
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THE CLINICAL SIGNIFICANCE OF MONITORING CARBOHYDRATE ANTIGEN CA50 IN COLORECTAL CARCINOMA |
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| Wang Kang,Liu Hao,Xu Yanra. THE CLINICAL SIGNIFICANCE OF MONITORING CARBOHYDRATE ANTIGEN CA50 IN COLORECTAL CARCINOMA[J]. Academic Journal of Xi’an Jiaotong University, 1998, 0(2) |
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| Authors: | Wang Kang Liu Hao Xu Yanra |
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| Abstract: | In order to iuvestigate the possibl. involvemeut of the antigen CA5o in petlents with colorectal carcinoma, the carbohydrate antigen CA50 serum vaiue. was examined in 30 normal individuals, 27 Patients with benign colomtal diseares and 66 Patieots with coloradoal cortinoma by lmmunoradiometric assay (IRMA). The results shoed that the serum CA50 value in patients with coloretalcarcinoma was significantly higher than that in petients with benign colorectal diseeees or in normalcontrol group (P< 0. 01). It significaotly declined after radical operation was performed (P<0. 01). However, no significant change was noted arter Palliative operation (P > 0. 05) and elevatedlevels noted with tumor recurrence. We concluded that the measurement of serum CA50 may be auseful marker for diagnosis and prognostic evaluation or Patients with colorectal carcinoma. |
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| Keywords: | colorectal carcinoma carbohydrate antigen CA50 diagnosis |
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