| 甲状腺上皮细胞DR抗原异常表达及影响因素 |
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| 引用本文： | 苏敏,牛恕淼.甲状腺上皮细胞DR抗原异常表达及影响因素[J].西安交通大学学报(医学版),1990(4). |
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| 作者姓名： | 苏敏 牛恕淼 |
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| 作者单位： | 西安医科大学病理解剖学教研室
(苏敏)，西安医科大学病理解剖学教研室(牛恕淼) |
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| 摘 要： | 本文应用单克隆抗体及免疫组化技术对37例自身免疫性甲状腺炎,23例甲亢及13例甲亢伴甲状腺炎甲状腺上皮细胞DR抗原异常表达进行原位研究。结果发现甲状腺上皮细胞DR抗原的异常表达与甲状腺浸润细胞总数、炎性破坏程度及外周血TSH、甲状腺球蛋白抗体、甲状腺微粒体抗体量呈正相关。
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| 关 键 词： | 自身免疫性甲状腺炎 甲亢 HLA-DR抗原 免疫组化 |
EFFECTS OF ABERRANT HLA-DR ANTIGEN EXPRESSION ON THYROCYTES |
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| Su Min,Niu Shumiao.EFFECTS OF ABERRANT HLA-DR ANTIGEN EXPRESSION ON THYROCYTES[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(4). |
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| Authors: | Su Min Niu Shumiao |
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| Institution: | Department of Pathology |
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| Abstract: | Tru-cut specimens of thyroid tissue from 37 cases of autoimmune thyroiditis, 23 cases of hyperthyroidism and 13 cases of thyrotoxicosis with thyroiditis were analyzed by immunohistochemistry using monodonal antibody specific for HIA-DR antigen. Results showed that thyroid epithelial cells aberrant expressed DR antigen and the number of DR~+ thyrocytes was significantly increased in thyroid gland with intense lymphocytes infiltration and severe destruction of throid architecture. The data suggest that TSH, thyroglobulin antibodies, thyroid microsomes antibodics can bring some stimulation HLA-DR antigen expression in thyrocytes. |
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| Keywords: | autoimmune thyroiditis hyperthyroidism HLA-DR antigen immunohistochemistry |
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