环加氧酶抑制剂和前列腺素受体阻断剂缓解糖尿病大鼠的痛过敏

目的　观察环加氧酶 (COX)抑制剂和前列腺素 (PG)受体阻断剂在糖尿病大鼠痛过敏中的作用。方法　给糖尿病痛过敏大鼠后爪背部皮下注射COX抑制剂消炎痛和meloxicam ,以及EP1型PG受体阻断剂SC 192 2 0 ,测定糖尿病痛过敏大鼠的伤害性爪回缩阈值 (NPWT)和热潜伏期 (TL)的变化。结果　经典的COX抑制剂消炎痛能长时间、显著缓解糖尿病大鼠的机械性痛过敏 ;选择性环加氧酶 2 (COX 2 )抑制剂meloxicam ,可短时间缓解糖尿病大鼠的机械性痛过敏和热痛过敏 ;选择性EP1型PG受体阻断剂SC 192 2 0能显著缓解糖尿病大鼠的机械性痛过敏和热痛过敏。结论　COX抑制剂和EP1型PG受体阻断剂能缓解糖尿病大鼠的痛过敏 ,提示PGs在糖尿病大鼠痛过敏的产生和维持中起重要作用

The relieving effect of cyclooxygenase inhibitors and prostaglandin receptor blocker on hyperalgesia of diabetic rats

Objective To observe the effects of cyclooxygenase (COX) inhibitors and prostaglandin (PG) receptor blocker on hyperalgesia of diabetic rats. Methods Nociceptive paw-withdrawal threshold (NPWT) and thermal latency (TL) of diabetic hyperalgesic rats were tested after subcutaneous injections of COX inhibitors indomethacin and meloxicam, and EP 1 PG receptor blocker SC-19220 into the dorsum of the hindpaw of the rats. Results Indomethacin, a classic inhibitor of COX, produced a significant and long-lasting relief of mechanical hyperalgesia in diabetic hyperalgesic rats. Meloxicam, a selective cyclooxygenase 2 (COX-2) inhibitor, alleviated mechanical and thermal hyperalgesia, but with a shorter duration. SC-19220, a selective EP 1 PG receptor blocker, produced significant relief of mechanical and thermal hyperalgesia. Conclusion COX inhibitors and EP 1 PG receptor blocker relieve hyperalgesia of diabetic rats, which suggests that PGs play an important role in inducing and maintaining hyperalgesia in diabatic rats.