Addison病60例临床分析及随访观察

<正> Addison病一般认为罕见,国内文献报告亦较少。本院自1955年至1982年共收治66例,占同期内科住院总人数2.2‰。现将资料较完整的60例的临床资料和部分病历的随访结果加以分析。

Clinical Analysis and Follow-up Observation of 60 Cases of Addison′s Disease

The Present paper reports the analysis of the clinical data of 60 cases of Addison's disease obtained from patients who were admitted to our hospital in 1955—1982, and the results of following up 20 patients. The etiology in this series tuberculosis accounted for 32 cases and 28 cases were associated with autoimmue adrenal atrophy. In the frequency of clinical manifastations, increased pigmentation, weakness and gastroentestinal symptoms were the most common. For the laboratory examination, we recommend the simple water load test and the cortisone-water load test because the positive ratio of the two tests was higher than that in the determination of the plasma cortisol and urinary 17—oH. In addtion, such tests were economic and simple. The treatment of Addison's disease by the replacement therapy was eff ective and glucocorticoids and/or glycyrrhiza were used in this series. The patient with adrenal crisis and cardiac arrest was Saved successfully. Of 20 patients followed up, 18 have recovered, 8 have stopped any drugs, only one died. One who was killed in a motoring accident was not recorded. In view of other endocrine gland diseases—diabetes mellitus or hyperthyroidism—in two cases, the mechanism and treatment of pluriglandular insufficiency are also discussed.