粘附分子E-Cadherin和CD_(44v6)表达与肺癌淋巴转移的关系

目的 探讨粘附分子E－Cadherin和CD44v6与肺癌淋巴转移的关系。方法 采用免疫组化SP法检测了63例肺癌组织及其中41例淋巴转移灶中E-Cadherin和CD４４v6的表达。结果 淋巴转移灶中CD４４v6阳性表达率为85..37%，显著高于原发灶(63..49%，P＜0..05)；ECadherin和CD４４v6均与肺癌淋巴转移密切相关(P值分别小于0..05和0..001)；诊断肺癌淋巴转移的敏感度和特异度E-Cadherin异常表达为63..41%和63..64%，CD４４ｖ６阳性表达为85..37%和77..27%，平行试验敏感度为87..80%，特异度为59..09%，系列试验敏感度为60..98%，特异度为81..18%。结论 E-Cadherin异常表达和CD４４ｖ６阳性表达可能均在肺癌淋巴转移中起重要的促进作用，可作为诊断肺癌淋巴转移的辅助指标。

The relationship between expression of cell adhesion molecules E-Cadherin and CD44v6 and lymph node metastasis in lung carcinoma

Objective To study the relationship between expression of cell adhesion molecules E-Cadherin and and lymph node metastasis in lung carcinoma. Methods Immunohistochemical SP method had been used to detect expressions of E-Cadherin and in 63 primary lung cancer tissues and 41 metastatic lymph nodes. Results The positive rate of expression in metastatic lymph nodes was 85.37 % (35/41), which was significantly higher than that in primary spots( P < 0.05). Either E-Cadherin or was distinctly correlated with lymph node involvements in lung cancer(P<0.05 and <0. 001 respectively). The sensitivity and the specificity of E-Cadherin abnormal expression positive expression, parallel and cascade test in diagnosing lymph node metastasis of lung cancer were 63.41% and 63.64%, 85.37% and 77.27%, 87.80% and 59.09%, 60.98% and 81.18%, respectively. Conclusion These results indicate that the E-Cadherin and CD44v6 play an important promoting role in lymph node metastasis in lung cancer.