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| 白藜芦醇对心肌缺血再灌注损伤的保护作用 | |
| 引用本文： | 黄伟,刘俊田,唐玉海,刘宏浪,史小莲,康爱群. 白藜芦醇对心肌缺血再灌注损伤的保护作用[J]. 西安交通大学学报(医学版), 2004, 25(6): 552-554 |
| 作者姓名： | 黄伟 刘俊田 唐玉海 刘宏浪 史小莲 康爱群 |
| 作者单位： | 1. 陕西医学高等专科学校内科,陕西西安,710068 2. 西安交通大学医学院药理学教研室,陕西西安,710061 3. 西安交通大学理学院化学系,陕西西安,710061 |
| 摘 要： | 目的 研究白藜芦醇 (Res)对心肌缺血再灌注损伤的保护作用。方法 通过建立大鼠心肌缺血再灌注模型 ,了解不同剂量白藜芦醇对心肌缺血再灌注损伤的保护作用。结果 Res呈剂量依赖性缩小大鼠缺血再灌注心肌梗塞范围 ;减少缺血再灌注心肌细胞内肌酸激酶 (CK)和乳酸脱氢酶 (LDH)的释放 ;降低心肌缺血再灌注诱发的ST T段的抬高 ;改善缺血再灌注心肌光镜下的细胞损伤。结论 Res对大鼠心肌缺血再灌注损伤有保护作用 |
| 关 键 词： | 白藜芦醇 心肌缺血再灌注损伤 心肌梗塞 脂质过氧化 |
| 文章编号： | 1671-8259(2004)06-0552-03 |
| 修稿时间： | 2004-05-12 |
The protective effect of Resvaratrol on myocardial ischemic-reperfused induced injury in rats |
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| Huang Wei,Liu Juntian,Tang Yuhai,Liu Honglang,Shi Xiaolian,Kang Aiqun. The protective effect of Resvaratrol on myocardial ischemic-reperfused induced injury in rats[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 2004, 25(6): 552-554 | |
| Authors: | Huang Wei Liu Juntian Tang Yuhai Liu Honglang Shi Xiaolian Kang Aiqun |
| Abstract: | Objective To study the protective effect of Res o n myocardial ischemic/reperfused induced injury. Methods My ocardial ischemic/reperfusion model was used to study the protective effect of d ifferent dosage resvaratrol on myocardial ischemic/reperfusion injury in rats. Results Res shrinked the size of myocardial infarction indu ced by the ischemic reperfused method, inhibited the release of creatine kinase( CK) and lactate dehydrogenase(LDH) from the injured myocardium and reduced elega ted ST-T of electrocardiogram(ECG) caused by myocardial ischemic-reperfused in jury in dose-dependent way. Res also improved the morphological changes of inju red myocardium. Conclusion Res has protective action on myo cardial ischemic reperfused injury in rats. |
| Keywords: | resvaratrol myocardial ischemic/reperfusion inju ry myocardial infarction salvia milticrrhiaze |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |