| 尸体肾移植中应用新山地明胶囊的临床观察 |
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| 引用本文： | 薛武军,陈勇,田普训,邢俊平,潘晓鸣,范小虎,燕航. 尸体肾移植中应用新山地明胶囊的临床观察[J]. 西安交通大学学报(医学版), 1997, 0(4) |
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| 作者姓名： | 薛武军 陈勇 田普训 邢俊平 潘晓鸣 范小虎 燕航 |
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| 作者单位： | 西安第一附属医院肾移植科!西安，710061(薛武军，陈勇，田普训，邢俊平，潘晓鸣，范小虎)，西安第一附属医院肾移植科!西(燕航) |
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| 摘 要： | 68例新接受肾移植的患者应用新山地明胶囊，其用量比山地明减少16.64％，全血浓度谷值维持稳定[3个月平均值（318．46±7826）μg／L]，仅1例发生急性排斥反应，4例发生肝毒性，3例发生肾毒性。18例由山地明或国产环孢素转换为新山地明的患者，免疫抑制效果满意，无排斥反应和明显的药物毒副作用，仅1例开始转换后出现过血肌研值升高。说明新山地明的生物利用度高，药物代谢动力学稳定，临床应用免疫抑制效果比山地明好。
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| 关 键 词： | 新山地明 移植 肾 |
CLINICAL STUDY OF USING SANDIMMUN NEORAL IN CADAVERIC RENAL TRANSPLANTATION |
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| Xue Wu jun, Chen Yong, Tian Puxun et al. CLINICAL STUDY OF USING SANDIMMUN NEORAL IN CADAVERIC RENAL TRANSPLANTATION[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1997, 0(4) |
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| Authors: | Xue Wu jun Chen Yong Tian Puxun et al |
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| Abstract: | 68 patients newly receiving renaltransplantation were treated with Sandimmun Neoral. The dosage of Sandimmun Neoral decreased16. 64% compared with Sandimmun, and the blood trough level was stable. The average blood trough level of Sandimmun Neoral was (318. 46 ±78. 26) μg/L within 3 months. One, four and three patients suffered from the acute rejection, hepatitis and nephrotoxicity, respectively. 18 patients transferred from Sandimmun to Sandimmun Neoral, the satisfying effect was achieved. There were no rejection or obvious toxic and side effects at the very beginning of using Sandimrnun Neoral. All the above indicate that Sandimmun Neoral has high bioavailability,stable blood trough level, and satisfactory immunosuppressive effect in clinic. Compared with the old Sandimmun, Sandimmun Neoral is more safe and more effective. |
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| Keywords: | Sandimmun Neoral transplantation kidney |
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