| L-赖氨酸锌和葡萄糖酸锌的药物动力学研究 |
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| 引用本文： | 吴松振,武国杰,杨蕾,张志峰.L-赖氨酸锌和葡萄糖酸锌的药物动力学研究[J].西安交通大学学报(医学版),1993(2). |
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| 作者姓名： | 吴松振 武国杰 杨蕾 张志峰 |
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| 作者单位： | 西安医科大学药学系无机化学教研室，西安医科大学二附院临床药理研究室，西安医科大学药学系无机化学教研室，西安医科大学卫生系仪器分析中心 西安 710061，西安 710061 87级毕业生 |
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| 摘 要： | 用原子吸收分光光度法,测定口服L—赖氨酸锌(Zinc L-lysinate)和葡萄糖酸锌(Zinc Glucosate)在家兔体内的血清锌浓度,并计算了它们的药代动力学参数。实验结果表明,葡萄糖酸锌在兔体内处置过程为一级动力学二房室模型,而L—赖氨酸锌近似于一级动力学一房室模型。二者的主要药代动力学参数分别为:葡萄糖酸锌,t_(1/2)(β)9.49h,T(p)1.3h,V/F(c)41.13 1/kg,Cl(S)13.14 1/kg.h,AUC 15.07 mg/kg·h;L—赖氨酸锌,t_(1/2)(ke)1.01h,T(p)1.08h,V/F 57.85 1/kg,Cl/F(s)39.631/kg·h,AUC 5.24mg/kg·h。
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| 关 键 词： | L-赖氨酸锌 葡萄糖酸锌 药物动力学 原子吸收分光光度法 |
PHARMACOKINETIC STUDY OF ZINC L-LYSINATE AND ZINC GLUCONATE IN RABBITS |
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| Wu Songzhen,Wu Guojie,Yang Lei.PHARMACOKINETIC STUDY OF ZINC L-LYSINATE AND ZINC GLUCONATE IN RABBITS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1993(2). |
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| Authors: | Wu Songzhen Wu Guojie Yang Lei |
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| Institution: | Wu Songzhen,Wu Guojie,Yang Lei Department of Inoranic Chemistry,Faculty of Pharmacy |
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| Abstract: | In this paper, the pharmacokinetic parametersof Zinc L-lysinate and Zinc Gluconate in rabbits arestudied by using the atomic absorption spectropho-tometry method. The results show that the serumconcentration-time curves of Zinc L-lysinate andZinc Gluconate in rabbit fit to one-compatmentmodel and a two-compartment model, respective-ly, The main pharmacokinetic parameters of ZincL-lysinate are: t_(1/2) (ke) 1. 01 h, T (p) 1. 08 h, andCI/F (s) 39. 63 1/kg. h; of Zinc Gluconate are: t_(1/2)(β) 9. 49h, T (p) 1. 3h, and Cl (s) 13. 14 1/kg. h. |
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| Keywords: | Zinc L-lysinate Zinc Gluconate pharmacokinetic atomic absorption spectrophotometry method |
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