肺癌性激素及其受体之间关系的研究

为研究肺癌的发病机制，探讨其性激素及其受体之间的关系，运用酶联亲合组化法对53例肺癌癌组织中雌激素受体（ER）和孕激素受体（PR）进行了检测，同时采用R抗体放射免疫分析法测定了患者外周血中的雌二醇（SEL）和孕酮水平（SPL）。结果显示ER阳性率49．1％，PR阳性率54．7％。SEL、SPL均有明显的升高（P<0．05），无论ER（＋）组还是ER（－）组，SEL均有显著的升高（P＜0．05）；ER（＋）组、PR（＋）组、ER（＋）和PR（＋）组的SEL、SPL较ER（－）组、PR（－）组、ER（－）和PR（－）组的相对低。提示受体阳性者更多地受到性激素的影响。

THE STUDY OF SEX HORMONES AND THEIR RECEPTORS IN THE BRONCHOGENIC CARCINOMA

Object To study the pathogenesis of Bronchogenic carcinoma and to learn the relationship Between sex hormones and their receptors, Methods Examining estradiol receptor and progesterone reCeptor in the tissues of 53 patients by using enzyme Linked affinity histochemical method, and examing estradiol level (SEL) and progesterone level (SPL)in the blood of the same person by using double andtibody radioimmune method .Results The postiive rates of ER and PR were 49.1% and 54.7% respectively . SEL and SPL rose notably (P<0.05).whether the results of ER and PR were positive of negative, SEL rose obviously than that of control Group (P<0.05). The SEL and SPL of ER( ) Group ,PR( )group . ER( )and PR( )group were lower than those of ER(-)group, PR(-) group ER(-) and PR(-)group. Conclusions Patients with ER( )and PR( ) are more influenced by sex hormones.