西安市男性吸烟、饮酒与食管癌关系的Meta分析

目的　探讨西安市男性吸烟、饮酒与食管癌的病因关系。方法　应用Meta分析对吸烟、饮酒与食管癌病例对照研究的文献进行综合评价。结果　纳入本次Meta分析的 5篇研究吸烟的文献中 ,病例组 5 30例 ,对照组 4 0 0 5例 ,异质性检验结果P >0 .0 5 ,支持固定效应模式 ,计算的OR为 2 .88(2 .32～ 3.5 8)。研究饮酒的 4篇文献中 ,病例组 4 6 5例 ,对照组 385例 ,异质性检验P <0 .0 5 ,按随机效应模式计算的OR为 1.81(1.0 8～ 3.0 5 )。结论　吸烟、饮酒与食管癌呈中等联系强度 ,是西安市男性食管癌的危险因素。

Meta analysis of the relationship between tobacco consumption, drinking and esophageal cancer among males in Xi'an

Objective To investigate the relationship between tobacco consumption, drinking andesophageal cancer among males in Xi' an. Methods We used meta analysis to evaluate the previous case-controlstudies on relationship between smoking, drinking and esophageal cancer. Results In this meta analysis, theheterogeneity test results of 5 literatures about the relation of smoking and cancer which recruited 530 cases and4005 controls supported the fixed effect model ( P > 0.05), whose pooled OR was 2.88 (95 % CI: 2.32 - 3.58)while the heterogeneity test results of 4 literature about the relation of drinking and cancer which recruited 465cases and 385 controls did not support the fixed effect model (P<0.05), whose pooled OR was 1.81 (95%CI:1.08 - 3.05) following the random effect model. Conclusion The correlation is of intermediate degree betweensmoking, drinking and esophageal cancer separately, which is the risk factor of esophageal cancer among males inXi'an.