| 久效磷致死性效应的毒理学研究 |
| |
| 引用本文： | 刘勇,龙曼海,罗沙菲,顾秋萍,金锡鹏.久效磷致死性效应的毒理学研究[J].西安交通大学学报(医学版),1988(1). |
| |
| 作者姓名： | 刘勇 龙曼海 罗沙菲 顾秋萍 金锡鹏 |
| |
| 作者单位： | 西安医科大学法医系
(刘勇)，贵州医学院
(龙曼海)，湖南医学院
(罗沙菲)，上海医科大学
(顾秋萍)，上海医科大学(金锡鹏) |
| |
| 摘 要： | 本文采用放射性核素示综枝术研究了久效磷在小鼠体内含量分布与致死性效应的关系,相应观察了不同致死剂量久效磷对小鼠血和脑胆碱脂酶活性抑制程度的差异。实验表明:久效磷急性中毒致死与脑内毒物的含量有较密切的关系。同时发现LD_(50)剂量中毒存活的小鼠,血和脑内胆碱脂酶活性受抑制程度与同剂量及超致死剂量中毒死亡小鼠之间无显著性差异。本文对久效磷致死的毒理机制造行了初步探讨。
|
A TOXICOLOGICAL STUDY ON LETHAL EFFECTS OF MONOCROTOPHO |
| |
| Liu Yong,et al.A TOXICOLOGICAL STUDY ON LETHAL EFFECTS OF MONOCROTOPHO[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1988(1). |
| |
| Authors: | Liu Yong |
| |
| Institution: | Faculty of Forensic Medicine |
| |
| Abstract: | The relation ship between lethal effects and the distribution of monocrotopho contents in the body of mice has been showed by using tracer determination of radioisotope. The authors also observed the difference of degree of inhibited cholinergic activity in blood and brain of mice to which monocrotopho was given orally in different lethal dose. The results showed that there was a close relatiom between the death of monocrotopho acute poison and toxicant contents in brain. At the same time, wealso found there was no significant difference between the degree of inhibited cholinergic activity in blood and brain of survival mice to which monocrotopho was given orally in LD_(50) and dead mice in same dose as well as in excess lethal dose. This paper deals with the toxicological mechanism of the death of monocrotopho poison. |
| |
| Keywords: | ~(14)C-monocrotopho lethal effects cholinergic activity radioactive activity |
| 本文献已被 CNKI 等数据库收录！ |
