感染过敏性关节炎的多抗甲素治疗及其病因学探讨

本题总结了100例感染过敏性关节炎的多抗甲素治疗及其病因学探讨的结果。随访观察六个月至四年,多抗甲素组(100例)治愈率84%;安慰剂对照组(20例)5%减轻,两组比较结果,P<0.005。并观测HLA20例、HLAB-7抗原阳性者55%,与对照组(7.14%)相比较,P<0.005,有统计学意义。本题探讨结果表明,多抗甲素具育抗炎、抗过敏、鉴别小儿生长痛和佐证说明本病病因学的作用。

ALPHA-POLYANTIGEN IN THE TREATMENT OF INFECTIOUS ALLERGIC ARTHRITIS, WITH DISCUSSION OF ETIOLOGY OF THE DISEASE

This paper summarizes the results the treatment of 100 cases with infectious allergic arthritis with alpha-Polyantigen and its etiologic analysis. After treatment in 90.48% of patients the joints swelling and pain subsided in 1-10 days; ESR, alpha-2, gama-globulin, C-3 decreased ( p < 0.001 ); ASO and CIC decreased (respectively P < 0.05 and 0.005 ); serum electrophoresi A and IgA increased (respectively p < 0.001 and 0.005). After 6 months to 4 years of follow-up the cure rate for the alpha-Polyantigen group (100 cases )was 84%, as compared with the placebo group ( 20 cases ) in which 95% of cases did not respond ( p < 0.05 ), with the Chloroquine-Tndocin group ( cure rate: 60.67% p < 0.005 ) and with the tonsillecto- mic group(cure rate: 37.5%; p<0.005). According to HLA in 20 cases there were 55% of cases with positive HLA-B-7 antigen, as compared with the control group ( 7.14%; p < 0.005) , howing that there is significant difference. The results show that alpha-polyantigen has nti-inflammatory and anti-allergic actions, by which the diagnosis of child growth-pain can be made and the etiology of the disease explored.