WWOX蛋白在非小细胞肺癌中的表达及其临床意义

目的 探讨WWOX(WW domain-containing oxidoreductase)基因在非小细胞肺癌组织中的表达及其临床意义.方法 用免疫组化方法检测50例鳞癌、31例腺癌及20例癌旁正常组织中WWOX基因蛋白的表达,并分析其与各临床病理指标之间的相关性.结果 WWOX基因在72.8%的非小细胞肺癌中失表达或表达减少,而在相邻正常肺组织中有80.0%正常表达.WWOX基因的表达与组织类型、细胞分化程度密切相关(P<0.05),在鳞癌和低分化癌中WWOX基因失表达或表达减少.结论 WWOX蛋白在非小细胞肺癌组织中呈低表达,该蛋白表达的缺失可能在不同类型非小细胞肺癌的形成中发挥了不同的作用.

WWOX gene expression in non-small cell lung cancer and its clinical significance

Objective To study the expression of WWOX gene in non-small cell lung cancer and its significance. Methods WWOX protein expression was evaluated by immunohistochemistry in 81 NSCLC patients(50 squamous cell carcinomas,31 adenocarcinomas and 20 adjacent normal lung tissues),and correlation with histopathologic(histotype,grade,tumor-node-metastasis,stage) and clinical characteristics was studied. Results WWOX expression was absent/reduced in 72.8% of NSCLC,whereas it was normal in 80.0% of adjacent normal lung tissues.WWOX expression was strongly associated with tumor histology and histologic grade(P <0.05),the percentage of cases with absent/strongly reduced WWOX expression was higher in squamous cell carcinomas and in poorly differentiated tumors. Conclusion The loss of WWOX expression plays a different role in tumorigenesis of distinct histotypes of NSCLC.