| 膜离子通道闸门调制剂对神经兴奋性的影响 |
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| 引用本文： | 王小民,陈婉梅.膜离子通道闸门调制剂对神经兴奋性的影响[J].西安交通大学学报(医学版),1992(2). |
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| 作者姓名： | 王小民 陈婉梅 |
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| 作者单位： | 西安医科大学神经生理学研究室,西安医科大学神经生理学研究室 西安 710061,西安 710061 |
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| 摘 要： | 在38例螯虾腹大神经和60例蟾蜍坐骨神经-腓神经标本上,观察了乌头碱(AC)、钙离子(Ca~(2+))和脱氧胆汁酸(DOC)3种膜离子通道闸门调制剂对神经兴奋性以及兴奋性指标—标准电量(a)的影响。结果表明,a与钠通道的激活速率有关,它可能反映了打开钠通道活化闸门、产生动作电位所需要的电量变化。
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| 关 键 词： | 钠通道 闸门电流 闸门调制剂 标准电量 |
EFFECTS OF GATING MODIFIERS OF MEMBRANE IONIC CHANNEL ON EXCITABILITY OF NERVES |
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| Wang Xiaomin,Chen Wanmei.EFFECTS OF GATING MODIFIERS OF MEMBRANE IONIC CHANNEL ON EXCITABILITY OF NERVES[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1992(2). |
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| Authors: | Wang Xiaomin Chen Wanmei |
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| Institution: | Research Laboratory of Neurophysiology |
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| Abstract: | Fffects of three gating modifiers of membrane ionic channel, aconitine (AC), deoxycholate (DOC) and Ca~(2+), on the excitability of nerves and the cxcitability index, standard clectrical quantity "a" were observed on 38 crayfish giant axons and 60 toad sciatic-peronael nerves. Results showed. that "a" is related to the activating rate of sodium channel and re(?)ts changes of clectrical quantity which is necded in opening the activation gating of sodium channel and producing the action potential. |
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| Keywords: | Na channcl Gating current Gating modifiers Standard clectrical quantity |
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