| 山豆根硷对家兔血小板聚集性的影响 |
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| 引用本文： | 刘俊田,邱培伦.山豆根硷对家兔血小板聚集性的影响[J].西安交通大学学报(医学版),1986(1). |
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| 作者姓名： | 刘俊田 邱培伦 |
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| 作者单位： | 西安医科大学药理学教研室
(刘俊田)，西安医科大学药理学教研室(邱培伦) |
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| 摘 要： | 本文观察了山豆根硷对家兔血小板聚集性的影响。结果表明,体内外给山豆根硷明显抑制ADP、AA和Coll诱导的血小板聚集,存在剂量依赖关系,在最大聚集率减少的同时:促进ADP、AA诱导的血小板聚集解聚,减慢Coll诱导血小板聚集速度;对三种促聚集剂的抑制无明显选择性。提示其作用机制可能与钙拮抗作用有关。
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EFFECT OF DAURICINE ON PLATELET AGGREGATION IN RABBITS |
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| Liu Juntian Qiu Peilun.EFFECT OF DAURICINE ON PLATELET AGGREGATION IN RABBITS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1986(1). |
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| Authors: | Liu Juntian Qiu Peilun |
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| Institution: | Department of Pharmacology |
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| Abstract: | It has been shown that dauricine possesses antiarrhymic and hypotensive actions. Our experimentation demonstrates that dauricine inhidits platelet aggregation induced by the threshold concentration of adenosine diphosphate (ADP), arachidonic acid (AA) and collagen (Coll) in the dose-dependent way in vitro in rabbits. The aggregatipn inhibition rates produced by dauri- cine 0.08 mg/ml for ADP, AA and Coll are 49.20%, 62.26% and 65.75% respectively. The adnimistration of dauricine 10 mg/kg to the rabbits intravenously also inhibits the platelet aggregation induced by the threshold concentration of ADP, AA and Coll, the aggregation inhibition rates being 40.12%, 32.71% and 21.21% respectively. The results show that the action mechanism of dauricine might be related to Ca-antagonism. |
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| Keywords: | platelet aggregation bdauricine |
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