| 实验性氟中毒大鼠骨软骨氨基多糖代谢的研究 |
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| 引用本文： | 李斯纯,莫晓燕,熊咏民,张矢远. 实验性氟中毒大鼠骨软骨氨基多糖代谢的研究[J]. 西安交通大学学报(医学版), 1995, 0(3) |
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| 作者姓名： | 李斯纯 莫晓燕 熊咏民 张矢远 |
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| 作者单位： | 西安医科大学地方性骨病研究所 西安710061 |
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| 摘 要： | 通过测定氟中毒大鼠骨、软骨氨基多糖各组分含量,观察过量氟化物对大鼠骨、软骨氨基多糖代谢的影响以及硼、硒、氟宁和苁蓉等药物的抗氟效果。结果表明,在本实验条件下,氟中毒时大鼠软骨己糖醛酸含量显著高于对照,而骨己糖醛酸和硫酸根含量低于对照。说明过量氟化物可影响骨、软骨氨基多糖代谢。从上述指标的生化改变来看,4种药物中苁蓉的抗氟作用显著。
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| 关 键 词： | 骨 软骨 氨基多糖 氟中毒 |
STUDIES ON THE METABOLISM OF CARTILAGE AND BONE GAG IN THE RATS WITH EXPERIMENTAL FLUOROSIS |
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| Li Sichun,Mo Xiaoyan,Xiong Yongmin,et al. STUDIES ON THE METABOLISM OF CARTILAGE AND BONE GAG IN THE RATS WITH EXPERIMENTAL FLUOROSIS[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1995, 0(3) |
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| Authors: | Li Sichun Mo Xiaoyan Xiong Yongmin et al |
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| Affiliation: | Institute of Endemic Bone Diseases |
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| Abstract: | The effects of excessive fluoride on bone and cartilage glycosaminoglycan ( GAG ) metabolism, as well as the effects of boron, selenium, serpention and desert cistanche aganist excessive fluoride were observed by determining the contents of GAG components including uronic acid, hexosamine and sulfate in bone and cartilage of the rats with experimental fluorosis. Uronic acid content in of the rats with experimental fluoro-sis was significantly higher than that in the control, but the contents of bone uronic acid and sulfate were decreased dramatically in comparison with the control. These suggest that excessive fluoride intake can interfere with the normal GAG. metabolism of bone and cartilage in rats, and among 4 drugs used in this experiment only desert cistanche has demonstrated the antagonistic effect on the excessive fluoride to a certain extent. |
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| Keywords: | born cartilage glycosaminoglycan fluorosis |
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