男性心肌梗塞病人血清性激素的变化及其意义

本文用放免方法检测了男性急性心肌梗塞(AMI)及陈旧性心肌梗塞(OMI)患者血清雌二醇(E_2)和辜酮(T)水平的变化。结果表明:①与对照组比较,AMI病人血清T显著降低(827.73±147.87ng/100ml VS 495.45±35.68ng/100ml,P<0.005),E_2无显著变化,E_2/T比值增大(0.011±0.001 VS 0.025±0.003,P<0.05);OMI病人血清E_2显著升高(80.36±15.86pg/ml VS 241.40±52.51pg/ml,P<0.001),而T无显著变化,E_2/T比值增大(0.011±0.001 VS 0.049±0.016,P<0.05)。②AMI与OMI组比较,OMI病人血清E_2、E_2/T比值显著增大(P<0.001,P<0.05),血清T虽有升高,但无显著差异。提示男性AMI及OMI病人血清E_2、T含量的变化方向不同,前者主要是T降低,后者主要是E_2升高,从而导致E_2/T比值增大,使性激素环境紊乱,可能在AMI的发病上起一定作用。

THE CHANGES OF SEX HORMONE IN MEN WITH MYOCARDIAL INFARCTION AND THEIR SIGNIFICANCE

We measured the serum estradiol (E_2) andtestosterone (T) in men with acute myocardialinfarction (AMI) and old myocardial infarction (OMI)by radioimmunoassay. The results showed com-pared with control group, the serum T decreasedsignificantly in AMI group (827.73±147.87 VS495.45±35.68 ng/100ml,P<0.005), while no signifi-cant changes in E_2 the ratio of E_2/T increased(0.011±0.001 VS O.025±O.003, P<0.05). In OMIgroup, serum E_2 inereased significantly (80.36±15.86VS 241.40±52.51 pg/ml P<0.001), while nomarked could be seen in T level, the ratio ofE_2/T increased (0.011±0.001) VS 0.049±0.016,P< 0.05). AMI group being compared with OMIgroup, there was an obvious increase in serum E_2 andratio of E_2/T (P<0.001, P<0.05) in OMI; althoughthe serum T level increased yet no significant differenceThe results indicate that the direction of the changes ofE_2 and T between AMI and OMI in men is not thesame in AMI T decreased obviously, while in OMI E_2increased markedly, Thereby, this results in the increaseof the ratio of E_2/T and the disturbance of the circum-stance of sex hormone, The disturbance may have an ef-fect on the pathogenesis of AMI