| 青藤碱对离体豚鼠心房的作用 |
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| 引用本文： | 李朝兴,赵更生.青藤碱对离体豚鼠心房的作用[J].西安交通大学学报(医学版),1986(1). |
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| 作者姓名： | 李朝兴 赵更生 |
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| 作者单位： | 西安医科大学药理学教研室
(李朝兴)，西安医科大学药理学教研室(赵更生) |
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| 摘 要： | 青藤碱27μM使离体豚鼠左房肌的收缩振幅和dT/dt_(max)分别降低51±11%和50±14%,抑制肾上腺素诱发的自律性,延长功能不应期,且呈剂量(2.7～270μM)依赖性变化,降低心肌的兴奋性。对右房的收缩幅度和频率也有抑制作用。提示青藤碱可能具有抑制Na~+,Ca~(++)内流的作用。
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EFFECTS OF SINOMENINE ON ISOLATED GUINEA-PIG AURICLE |
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| Li Chaoxing Zhao Gengsheng.EFFECTS OF SINOMENINE ON ISOLATED GUINEA-PIG AURICLE[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1986(1). |
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| Authors: | Li Chaoxing Zhao Gengsheng |
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| Institution: | Department of Pharmacology |
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| Abstract: | After Sinomenine 27 μM was given, the contractibility was decreased to 51±11% (SD) and dT/dt max to 50±14% (SD). The automaticity induced by epinephrine was inhibited. Sinomenine (2.7-270 μM) caused a concentration-dependent prolongation in the functional period. The amplitude of contraction and the heart rate in the right auricle was also inhibited. The results indicate that sinomenine may be antogonistic to both Ca~(++) influx and inward Na~(++) current. |
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| Keywords: | sinomenine auricle excitability |
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