| 大骨节病4种病因学说的同步研究 |
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| 引用本文： | 王治伦.大骨节病4种病因学说的同步研究[J].西安交通大学学报(医学版),2005,26(1):1-7. |
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| 作者姓名： | 王治伦 |
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| 作者单位： | 西安交通大学环境与疾病相关基因教育部重点实验室暨地方病研究所,陕西,西安,710061 |
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| 基金项目： | 国家科技攻关项目(No. 85 917 01 02)，国家自然科学基金项目(No. 39700667,30371245)，陕西省自然科学研究计划项目(No. 2001SM82)资助. |
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| 摘 要： | 目的 研究大骨节病的始动病因。方法 对大骨节病既往的生物地球化学说(低硒说)、水中有机物中毒说、粮食真菌毒素中毒说3种病因说及我们发现的病毒病因说进行同步研究,探讨该病的始动病因。结果 生物地球化学说(低硒说)、水中有机物中毒说、粮食真菌毒素中毒说均不是大骨节病的始动病因。大骨节病的病因模式应该是与环境条件下的生物毒素中毒(低硒条件下的人类微小病毒B19感染)有较大关联性。结论 大骨节病的始动病因可能是低硒条件下的人类微小病毒B19感染引起的。
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| 关 键 词： | 大骨节病 水中有机物 粮食真菌毒素 人类微小病毒B19 |
| 文章编号： | 1671-8259(2005)01-0001-07 |
| 修稿时间： | 2004年10月27 |
Synchronous study on the four kinds of etiological hypotheses of Kashin-Beck Disease |
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| Wang Zhilun.Synchronous study on the four kinds of etiological hypotheses of Kashin-Beck Disease[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2005,26(1):1-7. |
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| Authors: | Wang Zhilun |
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| Abstract: | Objective To study the initial etiology of Kashin-Beck Disease (KBD). Methods Three past etiological hypotheses, biology-earth-chemistry hypothesis (selenium deficient hypothesis), water organic compound poisoning hypothesis and food fungi toxin poisoning hypothesis were studied, together with the virus hypothesis we have developed synchronously to explore the initial etiology of KBD. Results Biology-earth-chemistry hypothesis (selenium absent hypothesis), water organic compound poisoning hypothesis and food fungi toxin poisoning hypothesis were not to be found the initial etiology of KBD. The etiology mode of KBD should be the biologic toxin poisoning under certain environmental condition. The human parvovirus B 19 infection under selenium deficient condition is significantly correlated with KBD. Conclusion The initial etiology of KBD may be the human Parvovirus B 19 infection under selenium absent condition. |
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| Keywords: | Kashin-Beck Disease water organic compound food fungi toxin human parvovirus B 19 |
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