In-vitro and in-vivo electrical characteristics of a penetrating microelectrode array for optic nerve electrical stimulation |
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Authors: | Xiao-hong Sui Yi-bin Shao Li-ming Li Xin-yu Chai Qiu-shi Ren |
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Institution: | (1) Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan;(2) Department of Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan;(3) Department of Electrical Engineering, Osaka University, Suita, Osaka, Japan |
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Abstract: | The Chinese C-Sight team aims to restore vision to blind patients by means of stimulating the optic nerve with a penetrating
microelectrode array. A biocompatible, implantable microwire array was developed having four platinum-iridium shafts, each
100 μm in diameter. This penetrating microwire array is described in this paper, including its fabrication techniques and
its in-vitro electrical characteristics. Every set of four shafts was spaced 0.4mm from center to center, comprising two short
shafts that were 0.3mm long and two that were 0.9mm long. This design was intended to stimulate ganglion cell axons at different
depths within the optic nerve. In-vitro electrochemical impedance testing results showed that the impedance at 1 kHz ranged
from 8 to 10 kΩ at room temperature. The voltage responses of the arrays to current pulse stimulation indicated a charge-injection
capacity of 210 μC/cm2. Finally, in-vivo acute animal experiments showed that the amplitude of the electrically evoked potentials (EEPs) measured
in primary visual cortex could be as large as 100 μV upon direct stimulation of the optic nerve. |
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