| 去甲斑蝥素在体外对白血病细胞核酸和蛋白质合成的影响 |
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| 引用本文： | 郭建芬,李广元,翁其亮,王广生. 去甲斑蝥素在体外对白血病细胞核酸和蛋白质合成的影响[J]. 西安交通大学学报(医学版), 1994, 0(3) |
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| 作者姓名： | 郭建芬 李广元 翁其亮 王广生 |
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| 作者单位： | 西安法医系毒理教研室，北京第四制药厂 |
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| 摘 要： | 应用细胞培养、放射性核素示踪技术研究了去甲斑蝥素对白血病细胞的作用。结果表明，去甲斑蝥素对人早幼粒白血病ＨＬ－６０细胞株ＤＮＡ和蛋白质合成有抑制作用，对ＲＮＡ合成未见明显影响；对正常人骨髓细胞ＤＮＡ合成无抑制相反有一定促进作用。
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| 关 键 词： | 去甲斑蝥素，白血病细胞，正常骨髓细胞，核酸，蛋白质 |
^EFFECTS OF NORCANTHARIDIN ON NUCLEIC ACID AND PROTEIN SYSTHESIS IN LEUKEMIC CELLS IN VITRO |
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| Guo Jianfen, Li Guangyuan,Weng Qiliang,et al. ^EFFECTS OF NORCANTHARIDIN ON NUCLEIC ACID AND PROTEIN SYSTHESIS IN LEUKEMIC CELLS IN VITRO[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1994, 0(3) |
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| Authors: | Guo Jianfen Li Guangyuan Weng Qiliang et al |
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| Abstract: | The cell culture and the radionuclide trace techiques were used in this study.The effect of Norcantharidin(NCTD) on leukemic cells was studied.The results showed that NCTD inhibited DNA and protien systhesis of human promyelocytic cell line HL-60,and that NCTD had no influence on RNA systhesis.The data showed that NCTD on normal bone marrow cells(NBMC)had no inhibition but a promotive deffect on DNA systhesis. |
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| Keywords: | norcantharidin leukemic cells normal bone marrow cells nucleic acid protein |
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