1.6-二磷酸果糖对大面积心肌梗塞后左室功能影响的实验研究

选用雄性wistar大鼠,随机分为心肌梗塞组(MI)、1,6二磷酸果糖(FDP)治疗MI组(FDPI)、假手术对照组(CS)及正常对照组(C)。高位结扎左冠状动脉造成大面积急性心肌梗塞,观察FDP对MI后左室泵功能及舒缩性能的影响。实验结果:1、各MI组间,梗塞范围无显著差异,但FDPI似有缩小趋势。2、MI与FDPI组间,心率、每搏量、每搏量指数无明显差异;FDPI的心输出量(CO)(40.6±8.3ml/min)及心指数(CI)(164.8±30.5ml/min/kg)较之MI的CO(30.6±10.2ml/min)及CI(127.2±36.8ml/min/kg)有明显的恢复(P<0.05)。3、MI与FDPI组间,血液动力学及心肌舒缩性能虽无明显差异,但FDPI也有好转趋势。结果表明,FDP确有改善大面积MI后心泵功能的作用。

THE EFFECT OF FRUCTOSE-1,6-DIPHOSPHATE ON THE LEFT VENTRICULAR FUNCTION AFTER MYOCARDIAL INFARCTION IN RATS

To observe the effect of fructote-1, 6-diphosphate (FDP) on left ventricular function after large infarcted size of myocardial infarction in male Wistar rats, rats were divided into four groups at rondom: (1) myocardial infarction (MI) by ligation of left coronary artery, (2) MI treated by FDP (FDPI), (3) sham--operated control (CS) and (4) normal control (C). The cardiac function was measured on the 3rd day after infareting.The results were: (1) The infaret size in FDPI seemed to be lesser than that in MI group. (2) There were no obvious differences in the values of heart rate, stroke volume and stroke volume index between MI and FDPI groups,cardiac output(CO)and cardiac index (CI) in FDPI group were significantly larger than those in MI group (CO: 40.6±8.3 ml/min vs 30.6±10.2ml/min; CI: 164±30.5ml/min/kg vs 127.2±36. 8ml/min/kg, all p<0.05. (3) There was no significant difference in contractile and relaxation function between FDPI and MI groups, The results indicated that FDP could improve the pumping function of heart following myocardial in faction.