| 室间隔缺损并肺动脉高压心肌超微结构改变的观察 |
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| 引用本文： | 李兆志,耿希刚,梁鸾仙,梁景仁,陈明霞,樊晓东.室间隔缺损并肺动脉高压心肌超微结构改变的观察[J].西安交通大学学报(医学版),1993(3). |
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| 作者姓名： | 李兆志 耿希刚 梁鸾仙 梁景仁 陈明霞 樊晓东 |
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| 作者单位： | 西安医科大学第一附属医院，西安医科大学第一附属医院，西安医科大学第一附属医院电镜室，西安医科大学第一附属医院，西安医科大学第一附属医院电镜室，西安医科大学第一附属医院 西安 710061，西安 710061，西安 710061，西安 710061 |
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| 摘 要： | 通过对10例空间隔缺损(VSD)并中、重度肺动脉高压(PH)患者右心房肌超微结构的观察,发现心肌微丝不同程度溶解消失,且在溶消区内可见粗面内质网池扩张,脂褐素增多及脂质小滴的出现;线粒体增生,其大小不等,分布不均,部分线粒体嵴消失,发生退行性变及基质电子密度降低;部分闰盘双膜间隙扩张,心肌纤维结缔组织增生。这些改变,可能与心肌慢性缺血缺氧有关。
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| 关 键 词： | 空间隔缺损 肺动脉高压 心肌活检 超微结构 |
THE OBSERVATION OF ULTRASTRUCTURAL CHANGE IN ATRIAL MYOCARDIUM BIOPSY FROM VENTRICULAR SEPTAL DEFECT WITH PULMONARY HYPERTENSION |
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| Li Zhaozhi,Geng Xigang,Liang Luanxian,et al.THE OBSERVATION OF ULTRASTRUCTURAL CHANGE IN ATRIAL MYOCARDIUM BIOPSY FROM VENTRICULAR SEPTAL DEFECT WITH PULMONARY HYPERTENSION[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1993(3). |
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| Authors: | Li Zhaozhi Geng Xigang Liang Luanxian |
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| Institution: | Li Zhaozhi,Geng Xigang,Liang Luanxian,et al Department of Surgery,First Affiliated Hospital |
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| Abstract: | The electromicroscopic observation of atrialbiopsy was carried out in 10 patients with ventric-ular septal defect (VSD) and middle, severe pul-monary hypertension (PH). The observation sug-gests that there are myofibrillar lysis to disappearwith various degrees, dilated rough endoplasmreticulum and the increase in lipofuscin granulesand lipid droplets; mitochondral hyperplasia, theirsize and shape being different, disorganizing of mi-tochondria, disintegration of cristae, mitochondralretrograde degenration and decreased matrix elec-tron density. The dilated intercalated discs and in-crease in myocardial fibrous tissue were found inpart of patients. These structural changes areprobably due to chronic myocardial ischemia. |
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| Keywords: | ventricular septal defect(VSD) pulmonary hypertension (PH) atrial myocardium biopsy ultrastructure |
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