大骨节病病因研究——病区天堂村饮水中有机物的测定(Ⅰ)

本研究应用XAD树脂富集,色谱/质谱联机分离鉴定的方法。对大骨节病病区(麟游县天堂村)三种饮水与对照(西安医科大学校园)深井水作了痕量有机化合物的测定分析。从天堂河水、深机井水、窑水与对照水样中分别检出了40种、31种、19种和10种有机化合物,且对每种检出物的结构式、分子量和峰面积均作了分析测定。其中芳核化合物分别为25种、19种、8种和4种。病区三种水样中均检出了烯类、烯酮类、酮类和萘类、苯并噻唑等稠环芳烃化合物;仅在河水和深井水样中检出了茚类化合物;在对照水样中未发现上述有机物。此结果未见文献报导。上述诸有机化合物可能是值得重视的可疑病因因素,但其真正的病因流行病学意义尚需进一步研究探讨。

STUDY ON WATERBONE ORGANIC COMPOUNDS AS THE CAUSE OF KASHIN-BECK DISEASE-ASSAY OF ORGANIC COMPOUNDS FROM DRINKING WATER IN AN ENDEMIC VILLAGE(1)

The study on the etiology of Kashin-Beck disease showed that organic residues in the large volume of water samples were concentrated onto XAD resin columns. The extracts were partioned and analyzed by GC/MS. The water samples from the endemic area of Kashin-Beck disease were collected from the Tian Tang river, deep well and cellar well which arc located in Tian Tang village, Linyou County, Shaanxi province. The control water sample was collected from a deep well on the campus of Xi'an Medical University which is the source of the University tap water. Forty, thirty one, nineteen and ten kinds of organic compounds, which were respectively found to embody twenty five, nineteen, eight and four kinds of aromatic compounds, were respectively discovered in the Tian Tang river, deep well, cellar well and control water. Alkenes, ketens, ketones, naphthalenes and thazoles were found only in the river, deep well and cellar well water. Indenes were merely found only in the river and deep well water. The results suggest that above six compounds may be important etiological factors of Kashin-Beck disease, which have never been reported. However, its real etiologcal and epidemiological signicance needs further study.