| bcl-2蛋白和PCNA在乳癌中表达的定量测定及其预后 |
| |
| 引用本文： | 王鸿雁,张学斌.bcl-2蛋白和PCNA在乳癌中表达的定量测定及其预后[J].西安交通大学学报(医学版),1999(1). |
| |
| 作者姓名： | 王鸿雁 张学斌 |
| |
| 作者单位： | 第一临床医学院病理科!西安７１００６１ |
| |
| 摘 要： | 应用图像分析仪对６０例乳癌ｂｃｌ－２、ＰＣＮＡ和雌孕激素受体进行免疫组织化学及酶联亲和法定量研究。结果表明：ｂｃｌ－２蛋白定量高值组，乳癌组织学分级低，患者生存期长、生存率高（Ｐ＜０．０５）；ＰＣＮＡ表达定量高值组，组织学分级高，患者生存期短、生存率低（Ｐ＜０．０５）。显示了定量检测ｂｃｌ－２蛋白和ＰＣＮＡ对评估乳癌分化程度及判断预后具有一定价值。ｂｃｌ－２与雌孕激素受体间有显著的正相关性（Ｐ＜０．００１），提示ｂｃｌ－２蛋白检测对乳癌患者内分泌治疗有重要参考价值。
|
| 关 键 词： | 乳腺癌 bcl－2蛋白 增殖细胞核抗原 免疫组织化学 图像分析系统 |
THE QUANTITATIVE MEASUREMENT OF EXPRESSION OF bcl-2 PROTEIN AND PCNA IN BREAST CARCINOMA AND THE RELATIONSHIP WITH HORMONE RECEPTOR AND PROGNOSIS |
| |
| Wang Hongyan, Zhang Xuebin.THE QUANTITATIVE MEASUREMENT OF EXPRESSION OF bcl-2 PROTEIN AND PCNA IN BREAST CARCINOMA AND THE RELATIONSHIP WITH HORMONE RECEPTOR AND PROGNOSIS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(1). |
| |
| Authors: | Wang Hongyan Zhang Xuebin |
| |
| Abstract: | bcl-2. PCAN and estrogen. progesterone receptors were examined in 60 breast carcinoma cases by immunoh is tochemical techniques andenzyme linked affinity histochemical methods. theresults of it were analyzed quantitatively by imageanalysis technique. The results were as follows:The more hcl-2 protein, the lower histologicalgrade;the longer survival term and the higher survival rate (P<0.05);the more PCNA, the highhistological grade, the shorter survival term and thelower survival rate (P<0. 05), which indicatedthat quantitative measuring of hcf-2 protein and PCNA expression was Of value in evaluating the degreeof differentiation and prognosis in breast carcinoma.A strong positive relationship was seen between hcf2 and ER.PR (P < 0. 001) and it showed a bettervalue for response to endocrine therapy in breastcarcinoma patients. |
| |
| Keywords: | breast Carcinoma hcl-2 protein I proliferating cell nuclear antigen immunohistochemistry image analysis technique |
| 本文献已被 CNKI 等数据库收录！ |
