| 怀牛膝皂甙A对动物子宫平滑肌的作用 |
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| 引用本文： | 郭胜民,车锡平,范晓雯.怀牛膝皂甙A对动物子宫平滑肌的作用[J].西安交通大学学报(英文版),1997(2). |
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| 作者姓名： | 郭胜民 车锡平 范晓雯 |
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| 作者单位： | 西安药学院!西安，710061，西安药学院!西安，710061，西安药学院!西安，710061 |
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| 基金项目： | 国家自然科学基金!39070943 |
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| 摘 要： | 观察了怀牛膝皂甙A对动物子宫平滑肌的作用。结果发现：给药后子宫收缩幅度增高，频率加快，张力增加，子宫收缩曲线下面积亦显著增加，并呈一定的浓度依赖关系。在0．12g／L浓度时，对不同生理状态下的大鼠离体子宫均有明显兴奋作用，但对幼龄子宫作用最弱，对晚孕子宫作用最强；对大鼠宫角平滑肌有明显兴奋作用，对宫颈兴奋作用不明显。在体家兔子宫实验发现，局部分别给子0．069／L、0．129／L及0．249／L的怀牛膝皂甙A均有明显兴奋未孕及已孕家兔在体子宫的作用。
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| 关 键 词： | 怀牛膝皂甙A 子宫兴奋 大鼠子宫 |
EFFECTS OF ACHYRANTHES BIDENTATA SAPONIN_A ON ANIMAL UTERI |
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| Cuo Shengmin, Che Xiping, Fan Xiaowen.EFFECTS OF ACHYRANTHES BIDENTATA SAPONIN_A ON ANIMAL UTERI[J].Academic Journal of Xi’an Jiaotong University,1997(2). |
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| Authors: | Cuo Shengmin Che Xiping Fan Xiaowen |
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| Abstract: | The characteristics of Achyranthes bidentata saponinA on isolated uteri from rat and rabbit uterus in situ were observed. The results of the experiments clearly proved that 0. 06mg/ml ~0.48mg/ml of ABSA usually caused a concentration-dependent excitant action in uterine preparations.0. 12mg/ml of ABSA yielded an evidently excitant ac-tion on isolated rat uteri under different physiologi-cal conditions, but the excitant action was weakest on immature uteri and strongest on late pregnant uteri. 0. 12mg/ml of ABSA did not cause an obvious-ly excitant action on rat cervix preparations. When ABSA was added into uterine tube, it could cause a clearly excitant action in both virgin and pregnant rabbit uteri in situ. |
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| Keywords: | achyranthes bidentata saponinA(ABS_A) uteri excitation rat uterus |
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