| 吗啡及纳洛酮对离体蟾蜍脊髓腹根反射影响 |
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| 引用本文： | 方秋文,梅俊. 吗啡及纳洛酮对离体蟾蜍脊髓腹根反射影响[J]. 西安交通大学学报(医学版), 1988, 0(1) |
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| 作者姓名： | 方秋文 梅俊 |
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| 作者单位： | 西安医科大学脑和神经生理研究室(方秋文)，西安医科大学脑和神经生理研究室(梅俊) |
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| 摘 要： | 本实验观察了镇疼药吗啡及其拮抗剂纳洛酮对离体蟾蜍脊髓腹根反射(VRR)的影响。发现小剂量吗啡(3.5×10~(-7)～10~(-5)M)对离体脊髓VRR具有兴奋作用,在一定范围内它与吗啡浓度呈正比关系。而大剂量(5.32×10~(-5)～8.08 ×10~(-5)M)吗啡则对VRR有抑制作用。单独施加纳洛铜于标本对VRR无兴奋或抑制作用,但当一定浓度吗啡兴奋标本时,加入纳洛酮可对抗其兴奋作用。进一步加大纳洛酮浓度,甚至可抑制VRR。实验资料提示纳洛酮可对抗吗啡对离体脊髓VRR的兴奋作用。
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EFFECTS OF MORPHINE AND NALOXONE ON THE VENTRAL ROOT REFLEX(VRR) OF TOAD SPINAL CORD IN VITRO |
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| Fang Qiuwen Mei Jun. EFFECTS OF MORPHINE AND NALOXONE ON THE VENTRAL ROOT REFLEX(VRR) OF TOAD SPINAL CORD IN VITRO[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1988, 0(1) |
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| Authors: | Fang Qiuwen Mei Jun |
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| Affiliation: | Research Laboratory of Brain and Nerve |
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| Abstract: | The effects of morphine and its antagnoist naloxone on the VRR were studied. Morphine, at lower concentration (3.5 × 10~(-7)～10~(-5)M), enhanced the VRR of toad spinal cord. This effect is proportional to its concentration within certain range, even though it depressed the ARR at higher concentration (5.3×10~(-5)-8.08×10~(-5)M). When naloxone was given alone. it did not excite or depress the VRR. While the VRR was enhanced by morphine, naloxone could antagonixe the exciting effect of the former. Experiments showed that naloxone could antagonize the exciting effect on the VRR produced by morphine. |
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| Keywords: | toad spinal cord in vitro ventral root reflex morphine naloxone |
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