| Phospholipase A2 changes and its significance on brain tissue of rat in severe acute pancreatitis |
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| 作者姓名： | 姚烜 陈喜 纪宗正 |
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| 作者单位： | Department of General Surgery, the Second Affiliated Hospital, Medical School of Xi＇an Jiaotong University, Xi＇an 710004, China |
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| 摘 要： | Objective To survey changes and the significance of phospholipase .42 （PLA2） on brain tissue of SD rat in acute pancreatitis. Methods With retrograde injection of 3% taurocholate sodium into pancreatic and biliary duct, rat model of severe acute pancreatitis （SAP） was made, and it included four groups： the control group, the shamoperation group, the SAP group and the PLA2 inhibitor-treated group of SAP. Serum amylases, PLA2 and PLA2 in brain tissue were measured and the brain tissue changes were observed. Results There were no significant difference in serum amylases, PLA2 and PLA2 in brain tissue between the sham-operation and the control groups; the levels of serum amylases, PLA2 and PLA2 in brain tissue in the SAP group were higher than those in the control. In the SAP group expansion and hemorrhage of meninges, intracephalic arteriolar hyperemia, in meninges and cephalic-parenchyma infiltration of inflammatory cells and interval broaden were observed, significant differences were found between two groups. Compared with the SAP group, the level of serum amylase, PLA2 and PLA2 in brain tissue were reduced significantly in the treatment group of SAP. Pathological damages in the treatment group were significantly reduced when compared with the SAP group. Conclusion PLA2 might play an important role in brain tissue damages in severe acute pancreatitis.
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| 关 键 词： | 重症急性胰腺炎 大鼠 脑组织 磷脂酶A2 病理 |
| 文章编号： | 1671-8267（2007）01-0110-02 |
Phospholipase A2 changes and its significance on brain tissue of rat in severe acute pancreatitis |
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| Yao Xuan,Chen Xi,Ji Zongzheng.Phospholipase A2 changes and its significance on brain tissue of rat in severe acute pancreatitis[J].Academic Journal of Xi’an Jiaotong University,2007,19(1):110-111,F0003. |
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| Authors: | Yao Xuan Chen Xi Ji Zongzheng |
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| Abstract: | Objective To survey changes and the significance of phospholipase A_2(PLA_2) on brain tissue of SD rat in acute pancreatitis.Methods With retrograde injection of 3% taurocholate sodium into pancreatic and biliary duct,rat model of severe acute pancreatitis(SAP) was made,and it included four groups: the control group,the sham-operation group, the SAP group and the PLA_2 inhibitor-treated group of SAP.Serum amylases,PLA_2 and PLA_2 in brain tissue were measured and the brain tissue changes were observed.Results There were no significant difference in serum amylases, PLA_2 and PLA_2 in brain tissue between the sham-operation and the control groups;the levels of serum amylases,PLA_2 and PLA_2 in brain tissue in the SAP group were higher than those in the control.In the SAP group expansion and hemorrhage of meninges,intracephalic arteriolar hyperemia,in meninges and cephalic-parenchyma infiltration of inflammatory cells and interval broaden were observed,significant differences were found between two groups.Compared with the SAP group,the level of serum amylase,PLA_2 and PLA_2 in brain tissue were reduced significantly in the treatment group of SAP.Pathological damages in the treatment group were significantly reduced when compared with the SAP group.Conclusion PLA_2 might play an important role in brain tissue damages in severe acute pancreatitis. |
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| Keywords: | pancreatitis phospholipases brain pathophisiology rat |
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