| EFFECT OF TASPINE ON WOUND HEALING AND FIBROBLAST PROLIFERATION |
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| 作者姓名： | 董亚琳 贺浪冲 陈方 |
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| 作者单位： | Department of Pharmacology，Medical School of Xi'an Jiaotong University，Xi'an 710061，China，Department of Pharmacology，Medical School of Xi'an Jiaotong University，Xi'an 710061，China，Department of Pharmacology，Medical School of Xi'an Jiaotong University，Xi'an 710061，China |
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| 摘 要： | Leonticerobustumisawellknownherbin QinbamountainareainnorthwestofChina.The numerouscompoundsfromtheplanthavebeenre ported1],e.g.taspine,methylcytisine,magnoflo rine,d lupamineandcaulosidesA,B,Cect.Itis reportedthattaspinehasanti inflammatory2], strong…
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| 关 键 词： | 塔斯品 成纤维细胞 伤口愈合 增殖 |
EFFECT OF TASPINE ON WOUND HEALING AND FIBROBLAST PROLIFERATION |
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| Dong Yalin,HE Langchong,Chen Fang.EFFECT OF TASPINE ON WOUND HEALING AND FIBROBLAST PROLIFERATION[J].Academic Journal of Xi’an Jiaotong University,2005,17(1):75-79. |
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| Authors: | Dong Yalin HE Langchong Chen Fang |
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| Institution: | Department of Pharmacology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China |
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| Abstract: | Objective To study the effect and mechanism of taspine on wound healing and fibroblast proliferation. Methods The effect of taspine on skin wound was observed in vivo. The different concentration of taspine hydrochloride was added to L929 fibroblast cultivated in vitro, and lactate dehydrogenase was detected and MTT method was applied to observe effect of taspine on fibroblast proliferation. Results The local application of taspine 3 mg/Ml and 1.5 mg/mL accelerated the healing of skin wounded. In vitro, 0.01～0.5 μg/mL of taspine hydrochloride showed no effect on the change of lactate dehydrogenase activity and fibroblast proliferation. Conclusion Taspine is a kind of active alkaloid from leontice robustum which can enhance wound healing, its mechanism on wound healing is not by means of accelerating the proliferation of fibroblast, other mechanisms are necessary for being further studied. |
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| Keywords: | leontice robustum taspine fibroblast wound healing |
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