| 细胞外ATP对大鼠脊髓损伤后运动功能恢复的影响 |
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| 引用本文： | 钱军,马延超,夏亚一,汉华,孙正义.细胞外ATP对大鼠脊髓损伤后运动功能恢复的影响[J].西安交通大学学报(医学版),2007,28(2):200-202. |
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| 作者姓名： | 钱军 马延超 夏亚一 汉华 孙正义 |
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| 作者单位： | 兰州大学第二医院骨科研究所,甘肃兰州,730030 |
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| 摘 要： | 目的研究细胞外ATP对大鼠脊髓损伤后运动功能恢复的影响。方法健康成年Wistar大鼠20只,雌雄不限,体重280-320 g,平均300 g,制作成脊髓打击伤动物模型,并随机分为两组:A组(ATP组)和B组(对照组),每组10只。伤后1、3、7、14、28 d用改良的Tarlov评分、斜板试验观察大鼠运动功能的恢复情况。结果大鼠脊髓损伤后A组改良的Tarlov评分、斜板试验优于对照组,在14 d和28 d,改良的Tarlov评分、斜板试验A组明显优于B组(P<0.05)。结论细胞外ATP能促进大鼠脊髓损伤后运动功能的恢复。
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| 关 键 词： | 脊髓损伤 ATP 运动功能 大鼠 |
| 文章编号： | 1671-8259(2007)02-0200-03 |
| 修稿时间： | 2006-07-03 |
Effects of extracellular ATP on the recovery of motor function after spinal cord injury in rats |
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| Qian Jun,Ma Yanchao,Xia Yayi,Han Hua,Sun Zhengyi.Effects of extracellular ATP on the recovery of motor function after spinal cord injury in rats[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2007,28(2):200-202. |
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| Authors: | Qian Jun Ma Yanchao Xia Yayi Han Hua Sun Zhengyi |
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| Institution: | Research Institute of Orthopaedics, the Second Hospital of Lanzhou University, Lanzhou 730030, China |
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| Abstract: | Objective To investigate the effects of extracellular ATP on the recovery of motor function after spinal cord injury in rats.Methods Twenty healthy adult rats were randomly divided into two groups after contusion injury was performed by the weight drop method at T10 with Allen impactor.Group A(ATP group) and group B(control group) each had ten rats.At days 1,3,7,14 and 28 after injury,the recovery of motor function after spinal cord injury in rats was assessed with modified Tarlov scores and slanting board test.Results Modified Tarlov scores and slanting board test were better in group A than in group B after spinal cord injury in rats.Significant difference was found in modified Tarlov scores and slanting board test between the two groups at days 14 and 28 after injury(P<0.05).Conclusion Extracellular ATP can promote the recovery of motor function after spinal cord injury in rats. |
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| Keywords: | ATP |
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