慢性特发性血小板减少性紫癜肾虚证免疫紊乱的临床研究

目的　探讨慢性特发性血小板减少性紫癜 (ITP)发病机理中肾虚与免疫紊乱的关系及二者如何参与该病发病机制。方法　根据中医辨证将 38例女性 ITP患者分为肾虚组和非肾虚组。肾虚组又分为肾阳虚组和肾阴虚组 ,测定 3组的血小板表面相关抗体 (PAIg G)和 T淋巴细胞亚群。结果　肾虚组 PAIg G明显高于非肾虚组 ,而 T辅助淋巴细胞与 T抑制淋巴细胞 (TH/TS)比值明显低于非肾虚组。肾阴虚组 TH/TS明显低于肾阳虚组 ,而 PAIg A和 PAIg M两组无显著差异。结论　本病多肾阴虚 ,其肾虚之本质是免疫紊乱

Immune Disorder and kidney deficiency in chronic idiopathic thrombocytopenic purpura

Objective To explore the relationship between kidney deficiency and immune disorder in the pathological mechanism of chronic idiopathic thrombocytopenic purpura and how they involve in the pathological mechanism.Methods According to the principle of differentiation of symptoms and signs of Traditional Chinese Medicine, 38 women patients suffering from chronic idiopathic thrombocytopenic purpura were divided into 2 groups:group of kidney deficiency, and group of non kidney deficiency.Group of kidney deficiency was further divided into Insufficiency of the Shen yang, and Insufficiency of Shen yin,PA IgG and subgroups of T lymphocytes of the 3 groups were determined.Then comparison was made among them.Results PA IgG of kidney deficiency group was markedly higher than that of Non kidney deficiency group.However ,the T H/T S ratio was considerably lower than that of Non kidney deficiency group.The T H/T S ratio of Shen yin insufficiency group was markedly lower than that of Shen yang insufficiency group.However ,no obvious difference between them was found in PA IgA and PA IgM.The number of cases of Shen yin deficiency was considerably larger than that of Shen yang insufficiency.Conclusion This disease mostly belongs to Shen yin insufficiency, and the nature of kidney deficiency is immune disorder.