| EFFECTS OF GALLIUM AND ITS COMBINATION WITH SELENIUM ON MOUSE S_180 SARCOMA AND BONE GALLIUM CONTENT |
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| 作者姓名： | 田东萍 李广元 张学斌 牛映斗 曹晖 |
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| 作者单位： | Department of Pathology，Xi'an Medical University，Xi'an 710061 |
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| 摘 要： | Gallium(Ga)isametalelementwhichbelongstogroupⅢaintheperiodictableanditisthemetalion,onlysecondtoplatinum(cip-pt),reportedtobeeffectiveintreatingcancerinliterature1].Moreover,manyclinicaltria1sc0nfirmedthatga1liumsalt(GaS)hadaremarkedlytherapeuticacti0nonthecancerrelatedhy-percalcemia">andPagetdiseaseofb0qe"'.Experimentalstudiesalsodem0nstratedthatGainhibitedboneres0rptioninvitroandincreasedCalcium(Ca)c0ntentofboneinvivo,Ourprevi0usinvestigati0nindicatedthatga1liumchloride(GaCl,)couldinhi…
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EFFECTS OF GALLIUM AND ITS COMBINATION WITH SELENIUM ON MOUSE S_(180) SARCOMA AND BONE GALLIUM CONTENT |
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| Tian Dongping, Li guangyuan, Zhang XuebinNiu Yingdou,Cao Hui.EFFECTS OF GALLIUM AND ITS COMBINATION WITH SELENIUM ON MOUSE S_180 SARCOMA AND BONE GALLIUM CONTENT[J].Academic Journal of Xi’an Jiaotong University,1997(1). |
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| Authors: | Tian Dongping Li guangyuan Zhang XuebinNiu Yingdou Cao Hui |
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| Abstract: | Kunming female mice were used and S180 sarcoma cells were transplanted subeutaneously into right anterior armpit or the mice. The mice were divided into three groups randomly, and orally administered with water, gallium chloride and GaCl3 Na2SeO3 respectively for 2 weeks. After that,the tumors and foreleg bones were taken out for study. The experimental results showed that oral administration with gallium chloride-could inhibit the growth or S180 sarcoma in mice and the tumor morphology was changed. Selenium could accelerate the gallium entering into bone. This fact might supply a new clue to further clinical application of gallium and selenium. |
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| Keywords: | gallium mouse S_(180) sarcoma selenium |
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