慢性肾功能不全患者血清一氧化氮水平及其在血液透析中的变化

应用硝酸还原酶法检测了 31例慢性肾功不全患者及 2 6例血液透析( HD)患者血透过程中血清一氧化氮 ( s- NO)水平的变化。结果表明 :慢性肾衰患者 s-NO水平明显升高 ( P <0 .0 0 1 ) ;合并高血压组 s- NO水平低于无高血压组 ( P <0 .0 5 ) ;HD过程中 s- NO浓度逐渐下降 ,HD2 h、HD4h与透析前比较差别显著 ( P <0 .0 0 1 ) ;透析过程中血压升高与 s- NO下降有一定关系。结论 :慢性肾功衰竭患者 s-NO水平升高可能与肾功能明显减退有关 ;HD能清除硝酸盐 ,透析中 s- NO下降可能是导致透析中血压升高的原因之一。

THE CONCENTRATION OF SERAL NITRIC OXIDE IN PATIENTS WITH CHRONIC RENAL INSUFFICENCY AND ITS VARIATION DURING HEMODIALYSIS

We used nitric acid reductase method to test nitric oxide of serum(s NO) in 31 patients with chronic renal failure(CRF).We observed the variations of s NO and the blood pressures in 26 who were treated with hemodialysis (HD) .The results showed that the concentration of s NO in patients was higher than that of normal(P<0 001);s NO of patients with hypertension was lower than that of patients without hypertension (P<0 05).Compared with the s NO concentration of pre HD, the s NO level of post HD2h and post HD4h were much lower (P<0 001).There was a negative relative trend between hypertension and s NO decreasing during HD period.In conclusion, our study indicates that the rising of s NO of patients with CRF may be related to serious renal failure;s NO can be cleared by HD and the decreasing of s NO may be one of the reasons that results in rising of blood pressure during HD.