大骨节病病区不同病情学龄儿童尿中肌酐含量的研究

1.大骨节病不同病情学令儿童尿中肌酐含量不同。 2.大骨节病不同病期儿童尿中肌酐含量呈现有规律的变化。其中只有进展期患儿尿肌酐含量明显低于非病区儿童。 3.大骨节病肌肉代谢障碍主要表现为能量代谢失调。尿肌酐含量减少的发病机制被认为与肌细胞中线粒体内cp合成减少有关,影响cp合成减少的因素可能有①肌酸合成减少;②ATP生成减少;③CPK同功酶活性改变。大骨节病患儿肌肉萎缩现象似属于消耗性分解并非坏死性质,其机制可能与机体在疾病状态下对具有ATP酶活性的肌球蛋白的需求增加有关。 4.外环境的低硒因素很可能就是大骨节病肌酐代谢抑制因子。

Study on Creatinine Content in urine of Children with Kashin-Beck′s Disease of Different Stages

Kashin-Beck's disease (KBD) is an endemic arthrosis and though its cause is still unknown it usualIy occurs in theselenium-defieiency areas. Moscular atrophy of variuos degrees has been found in children with KBD, besides damage to hyaline cartilage. The creatinine content in the urine of children with KBD of different stages was determined. It was found that the creatinie content in the urine was significantly Iower in children with advanced KBD than in normal children, but in the recovery sta(?)e of KBD it was slightly lower in diseased children than in normal children. It was suggested that there might be an unknown environmental factor (s) in the selenium-deficiency areas, which may lead to a decrease in the creatinine content in the urine. Selenium-deficiency might relate to a decrease in the creatinine content in the urine of children with KBD.