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| 肥大心肌缝隙连接的超微结构及临床意义 | |
| 引用本文： | 杨琳,陈明霞,刘衍晟,原卫清,陈恒馥,杨少毅.肥大心肌缝隙连接的超微结构及临床意义[J].西安交通大学学报(医学版),1999,20(3):3. |
| 作者姓名： | 杨琳 陈明霞 刘衍晟 原卫清 陈恒馥 杨少毅 |
| 作者单位： | 1. 西安医科大学第一临床医学院心内科,西安,710061 2. 西安医科大学第一临床医学院电镜室,西安,710061 3. 西安医科大学第一附属医院心内科 |
| 基金项目： | 为院基金项目 |
| 摘 要： | 采用电镜冷冻蚀刻和超薄切片的方法观察了大鼠腹主动脉狭窄致左室肥厚心肌细胞缝隙连接（ＧＪ）的结构特点。结果发现，心肌细胞超微结构损伤严重，闰盘肿胀、扩张，冷冻蚀刻法见ＰＦ面颗粒排列紊乱、颗粒的中心距离变大。这种细胞间电活动传导通路的结构变化，可认为是高血压心肌肥大时产生心律失常的一种基础 |
| 关 键 词： | 肥大心肌 缝隙连接 冷冻蚀刻 |
THE UITRASTRUCTURE OF GAP JUNCTION OF HYPERTROPHIC CARDIAC MYOCYTES AND ITS CLINICAL SIGNIFICANCE |
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| Yang Lin.THE UITRASTRUCTURE OF GAP JUNCTION OF HYPERTROPHIC CARDIAC MYOCYTES AND ITS CLINICAL SIGNIFICANCE[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999,20(3):3. | |
| Authors: | Yang Lin |
| Abstract: | We adopt the methods of freezing fracture and thin section electron micrographs to abserve the characteristics of the gap junctions from left ventricular hypertrophy (LVH) in rat caused by constricting the aorta.The Ultrastructure of cardiac myocytes in LVH group was heavily demaged.The intercalated disk swollen and dilatated.The arrangement of P face was dispersed and the distribution of center to center distance between P face particles bacame large.The construction modification of low resistance pathway for transmission of electrical current among myocytes can be considered as a foundation of arrhythmia in hypertention and patients with left ventricular hypertrophied. |
| Keywords: | hypertrophic cardiac myocytes gap junction freezing fracture |
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