| 原癌基因c-erbB2和EGFR表达与大鼠肺纤维化的相关性 |
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| 引用本文： | 李龙,余勤,胡建明. 原癌基因c-erbB2和EGFR表达与大鼠肺纤维化的相关性[J]. 西安交通大学学报(医学版), 2011, 32(6): 722-724,732 |
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| 作者姓名： | 李龙 余勤 胡建明 |
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| 作者单位： | 兰州大学第一医院呼吸科,甘肃兰州,730000 |
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| 基金项目： | 甘肃省科技厅资助项目(No.0709TCYA070)~~ |
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| 摘 要： | 目的研究原癌基因c-erbB2和肺表皮生长因子受体(EGFR)的表达与大鼠肺纤维化的相关性,探讨肺纤维化的发生机制。方法采用博莱霉素气管注射法制造鼠肺纤维化模型。30只Wistar大鼠随机分为模型组和对照组,分别于第1、14、28天处死大鼠5只并留取标本,采用免疫组化SP法检测在不同程度肺纤维化条件下c-erbB2和肺内源性EGFR的表达,分析其与肺纤维化的相关性。结果①模型组c-erbB2和EGFR表达在各时间点均与对照组有统计学差异(P<0.01);②模型组c-erbB2表达1d最显著,EGFR表达28d达到顶峰,与同组其他时间点均有统计学差异(P<0.01);③模型组c-erbB2和EGFR水平在第14天与最低水平组(分别为第28天和第1天)比较有统计学差异(P<0.01);④模型组c-erbB2和EGFR表达与肺纤维化程度密切相关(相关系数r分别为-0.835和0.77,P<0.01)。结论 c-erbB2活化的同时,EGFR表达也逐渐增强,且c-erbB2、EGFR的活化水平与肺纤维化程度密切相关;c-erbB2和EGFR激活可能参与了肺纤维化的发生。
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| 关 键 词： | 肺纤维化 原癌基因 c-erbB2 表皮生长因子受体 相关性 |
Expressions of epidermal growth factor receptor and c-erbB2 in pulmonary fibrosis in rats |
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| LI Long,YU Qin,HU Jian-ming. Expressions of epidermal growth factor receptor and c-erbB2 in pulmonary fibrosis in rats[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 2011, 32(6): 722-724,732 |
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| Authors: | LI Long YU Qin HU Jian-ming |
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| Affiliation: | LI Long,YU Qin,HU Jian-ming(Respiratory Department,the First Hospital of Lanzhou University,Lanzhou 730000,China) |
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| Abstract: | Objective To study the expressions of epidermal growth factor receptor(EGFR) and c-erbB2 in pulmonary fibrosis in rats.Methods Thirty Wistar rats were randomly divided into the pulmonary fibrosis group and the control group.Five rats were sacrificed after treatment on days 1,14 and 28,respectively,and their lungs were harvested for histological studies.The expressions of EGFR and c-erbB2 in pulmonary fibrosis of different degrees were determined by immunohistological SP method and their correlation with pul... |
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| Keywords: | pulmonary fibrosis oncogene c-erbB2 epidermal growth factor receptor(EGFR) correlation |
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