| 银杏叶提取物对帕金森病模型大鼠多巴胺神经元的保护作用 |
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| 引用本文： | 冯建军,李雅丽,侯辰,李立博,张巧俊.银杏叶提取物对帕金森病模型大鼠多巴胺神经元的保护作用[J].西安交通大学学报(医学版),2011,32(6):783-786. |
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| 作者姓名： | 冯建军 李雅丽 侯辰 李立博 张巧俊 |
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| 作者单位： | 1. 西安交通大学医学院第二附属医院老年神经科,陕西西安,710004
2. 西安交通大学医学院第二附属医院脑病科,陕西西安,710004 |
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| 基金项目： | 2007陕西省中医药管理局中医药科研项目(No.2007-80)~~ |
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| 摘 要： | 目的 探讨银杏叶提取物(EGb)对部分损毁的帕金森病(PD)模型大鼠多巴胺(DA)能神经元的保护作用及其可能机制.方法 65只健康雄性SD大鼠随机分为4组:对照组、PD组、银杏叶提取物(EGb)低剂量组(20 mg/kg)和高剂量组(40 mg/kg).采用免疫组化法观察大鼠黑质酪氨酸羟化酶(TH)阳性细胞数目的变化,...
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| 关 键 词： | 银杏叶提取物 帕金森病 多巴胺神经元 谷胱甘肽过氧化物酶 丙二醛 |
The neuron-protective effect of ginkgo biloba extract on rat models of Parkinson's disease |
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| FENG Jian-jun,LI Ya-li,HOU Chen,LI Li-bo,ZHANG Qiao-jun.The neuron-protective effect of ginkgo biloba extract on rat models of Parkinson's disease[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2011,32(6):783-786. |
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| Authors: | FENG Jian-jun LI Ya-li HOU Chen LI Li-bo ZHANG Qiao-jun |
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| Institution: | FENG Jian-jun1,LI Ya-li2,HOU Chen2,LI Li-bo2,ZHANG Qiao-jun2(1.Department of Geriatric Neurology,2.Department of Encephalopathy,the Second Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710004,China) |
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| Abstract: | Objective To explore the neuron-protective effect of ginkgo biloba extract(EGb) on partially-damaged rat Parkinson's disease(PD) models.Methods Sixty-five rats were randomly assigned into four groups: control group,PD group,low-(20 mg/kg) and high-(40 mg/kg) dose EGb groups.Quantitative immunohistochemistry was used to detect the number of neurons expressing hydroxylase(TH) in substantial nigra pars compacta(SNc),and contents of glutathione peroxidase(GSH-PX),maleic dialdehyde(MDA) and superoxide dismutase(... |
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| Keywords: | ginkgo biloba extract Parkinson's disease dopamine neuron glutathione peroxidase maleic dialdehyde |
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