| 国产氨利酮十二指肠给药对犬血流动力学的影响 |
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| 引用本文： | 庄斐尔,赵更生,张殿增,丁宝兴,高晓利. 国产氨利酮十二指肠给药对犬血流动力学的影响[J]. 西安交通大学学报(医学版), 1990, 0(2) |
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| 作者姓名： | 庄斐尔 赵更生 张殿增 丁宝兴 高晓利 |
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| 作者单位： | 西安医科大学药理学教研室(庄斐尔，赵更生，张殿增，丁宝兴)，西安医科大学药理学教研室(高晓利) |
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| 摘 要： | 国产氨利酮(5-20mg/kg)给麻醉犬十二指肠用药后,血流动力学参数LVSP、dp/dt max、Vce-+dp/dtmax及CI显著增加,而TPR及T Value明显降低,SBP、MAP及HR均无明显变化。结果说明,口服氨利酮既具正性肌力,又有扩张血管作用,是一种新型的改善心功的强心药。
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| 关 键 词： | 氨利酮 血流动力学 十二指肠 |
EFFECT OF DUODENALLY ADMINISTERED DOMESTIC AMRINONE ON HEMODYNAMICS IN ANESTHETIZED DOGS |
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| Zhuang Feier,et al. EFFECT OF DUODENALLY ADMINISTERED DOMESTIC AMRINONE ON HEMODYNAMICS IN ANESTHETIZED DOGS[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1990, 0(2) |
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| Authors: | Zhuang Feier et al |
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| Affiliation: | Department Pharmacology |
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| Abstract: | Domestic Amrinone(AMR, 5-20mg/kg) duodenally administrated in the anesthetized dogs increased significantly left ventricular systolic pressure (LVSP), maximal rate of change of intr aventricular pressure (dp/dtmax), Vce at dp/dtmax (Vce-+dp/dtmax), and cardiac index(CI) of hemodynamic parameters, while total peripheral resistance(TPR) and the time constant of isovolumic diastolic pressure decay (T Value) were decreased significantly, and no significant change in systolic blood pressure (SBP), mean artery blood pressure (MAP) and heart rate(HR) occurred. It suggests that orally given AMR should have both inotropic and vasodilatory. It is a new potent cardiotonic drugs of improving cardiac functions. |
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| Keywords: | Amrinone hemodynamics duodenum |
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